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Transient receptor potential cation channel subfamily M member 5
go.drugbank.com/bio_entities/BE0020643TargetHumansMediates the transport of Na(+), K(+) and Cs(+) ions equally well (PubMed:14634208). Activated directly by increase in intracellular Ca(2+), but is impermeable to it (PubMed:14634208). … diacylglycerol (DAG) and inositol trisphosphate (IP3), IP3 binds to its receptors in the endoplasmic reticulum and cause calcium release.
Synonyms: MLSN1- and TRP-related gene 1 proteinHydroxyproline dehydrogenase
go.drugbank.com/bio_entities/BE0020644EnzymeHumansCan also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. … Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis
Synonyms: Kidney and liver proline oxidase 1Avacincaptad pegol
go.drugbank.com/drugs/DB15165ApprovedInvestigationalThis approval is based on the positive results obtained from 2 phase 3 clinical trials GATHER1 and GATHER2.[L47701] … It was developed to treat an advanced form of age-related macular degeneration (AMD) called geographic atrophy (GA).
Categories: Nucleic Acids, Nucleotides, and NucleosidesLusutrombopag
go.drugbank.com/drugs/DB13125ApprovedInvestigationalLusutrombopag is currently in phase III development in various European countries including Austria, Belgium, Germany, and the UK [A36730]. … Lusutrombopag binds to the transmembrane domain of TPOR expressed on megakaryocytes, and causes the proliferation and differentiation of megakaryocytic progenitor cells from hematopoietic stem cells [FDA
Categories: Blood and Blood Forming OrgansFenoprofen
go.drugbank.com/drugs/DB00573ApprovedAn anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Categories: Antiinflammatory and Antirheumatic Products, Antiinflammatory and Antirheumatic Products, Non-SteroidsGrazoprevir
go.drugbank.com/drugs/DB11575ApprovedGrazoprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 [synthesis]. … Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV).
Mixtures: ZEPATIER FILM-COATED TABLET 50MG/100MGCategories: elbasvir and grazoprevirPotassium channel subfamily T member 2
go.drugbank.com/bio_entities/BE0015626TargetHumansSodium-activated and chloride-activated potassium channel (PubMed:14684870, PubMed:16687497, PubMed:25214519, PubMed:27682982, PubMed:29069600, PubMed:29740868).
Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1, Sequence like an intermediate conductance potassium channel subunitAcenocoumarol
go.drugbank.com/drugs/DB01418ApprovedInvestigationalAcenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. … [A188739] Hematocrit, hemoglobin, international normalized ratio and liver panel should be monitored. Patients on acenocoumarol are prohibited from giving blood.
Categories: Warfarin and isomers, Blood and Blood Forming OrgansSulfadimethoxine
go.drugbank.com/drugs/DB06150ApprovedVet approvedWithdrawnIn the US, sulfadimethoxine is one of the products that have been withdrawn or removed from the market after being found to be unsafe or not effective.[L43942] … It is widely available in Russia as an over-the-counter drug manufactured by a number of Russian pharmaceutical companies.
Categories: Sulfonamides and trimethoprim, Genito Urinary System and Sex HormonesAmifostine
go.drugbank.com/drugs/DB01143ApprovedInvestigationalIt causes splenic vasodilation and may block autonomic ganglia.