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Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
go.drugbank.com/bio_entities/BE0000628TargetHumansLow affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells
Polypeptides: Granulocyte-macrophage colony-stimulating factor receptor subunit alphaScavenger receptor cysteine-rich type 1 protein M130
go.drugbank.com/bio_entities/BE0003375TargetHumansAcute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage.
Polypeptides: Scavenger receptor cysteine-rich type 1 protein M130Synonyms: Hemoglobin scavenger receptorPutative high affinity immunoglobulin gamma Fc receptor IB
go.drugbank.com/bio_entities/BE0004684TargetHumansMay bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response
Polypeptides: Putative high affinity immunoglobulin gamma Fc receptor IBSynonyms: IgG Fc receptor IB, Fc gamma receptor IB pseudogeneNuclear receptor subfamily 4 group A member 3
go.drugbank.com/bio_entities/BE0008998TargetHumansIn mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). … In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity).
Polypeptides: Nuclear receptor subfamily 4 group A member 3Synonyms: Nuclear hormone receptor NOR-1, Neuron-derived orphan receptor 1Nuclear receptor subfamily 1 group D member 2
go.drugbank.com/bio_entities/BE0009348TargetHumansActs as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. … Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced
Polypeptides: Nuclear receptor subfamily 1 group D member 2Synonyms: Rev-erb alpha-related receptor, Orphan nuclear hormone receptor BD73Leukocyte immunoglobulin-like receptor subfamily A member 4
go.drugbank.com/bio_entities/BE0013620TargetHumansFunctions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic ...
Polypeptides: Leukocyte immunoglobulin-like receptor subfamily A member 4Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
go.drugbank.com/bio_entities/BE0020703TargetHumansGreatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232).
Polypeptides: Peroxisome proliferator-activated receptor gamma coactivator 1-alphaDuvelisib
go.drugbank.com/drugs/DB11952ApprovedInvestigationalcan produce a broad adaptative and innate immune cell inhibitory activity. … Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma
Attapulgite
go.drugbank.com/drugs/DB01574ApprovedVet approvedWithdrawnWhen used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. … Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States.
Categories: Compounds used in a research, industrial, or household settingEnalapril
go.drugbank.com/drugs/DB00584ApprovedInvestigationalVet approvedEnalapril is an orally-active and long-acting nonsulphydryl antihypertensive agent that suppresses the renin-angiotensin-aldosterone system to lower blood pressure. … It is also found in a combination product containing [hydrochlorothiazide] that is used for the management of hypertension.
International brands: Vasotec IV