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Displaying results 2561 - 2570 of 2744 in total
  1. Target

    Splicing factor, proline- and glutamine-rich

    go.drugbank.com/bio_entities/BE0008965
    TargetHumans

    Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune … The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity.

    Synonyms: DNA-binding p52/p100 complex, 100 kDa subunit
  2. Target

    Inter-alpha-trypsin inhibitor heavy chain H2

    go.drugbank.com/bio_entities/BE0009060
    TargetHumans

    May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are ...

    Synonyms: Inter-alpha-trypsin inhibitor complex component II
  3. Target

    Inter-alpha-trypsin inhibitor heavy chain H1

    go.drugbank.com/bio_entities/BE0009080
    TargetEnzymeHumans

    May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are ...

    Synonyms: Inter-alpha-trypsin inhibitor complex component III
  4. Drug

    Fulzerasib

    go.drugbank.com/drugs/DB21609
    Investigational

    The usage of the INN stem '-rasib' in the name indicates that Fulzerasib is a Ras protein inhibitor.

  5. Target

    Proteasome subunit alpha type-6

    go.drugbank.com/bio_entities/BE0003915
    TargetHumans

    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

    Synonyms: Multicatalytic endopeptidase complex iota chain
  6. Drug

    Desmopressin

    go.drugbank.com/drugs/DB00035
    ApprovedInvestigational

    First synthesized in the 1960s, desmopressin has remained a gold-standard therapy for water balance disorders due to its safety and long duration of action compared to natural AVP [A31661, A275461].

    Categories: Sex Hormones and Insulins
  7. Drug

    Alfuzosin

    go.drugbank.com/drugs/DB00346
    Approved

    Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-6...

    Categories: Genito Urinary System and Sex Hormones
  8. Drug

    Cinacalcet

    go.drugbank.com/drugs/DB01012
    ApprovedInvestigational

    Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.

    Categories: Sex Hormones and Insulins
  9. Drug

    Pasireotide

    go.drugbank.com/drugs/DB06663
    ApprovedInvestigational

    Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease.

    Categories: Sex Hormones and Insulins
  10. Drug

    Varicella zoster vaccine (live/attenuated)

    go.drugbank.com/drugs/DB10318
    ApprovedInvestigational

    Other complications also include bacterial infection, spread of the shingles rash to the eye (herpes zoster ophthalmicus) or ear, nerve palsies, or spread of VZV to non-immune persons via contact with

    Categories: Complex Mixtures