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Displaying results 2571 - 2580 of 10000 in total
  1. Drug

    Polysorbate 80

    go.drugbank.com/drugs/DB11063
    ApprovedInvestigational

    Polysorbate 80 is a hydrophilic nonionic surfactant. It is utilized as a surfactant in soaps and cosmetics and also as a lubricant in eye drops. … Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration or vaccinations.

    Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsSynonyms: Tween 80, Polysorbate 80
  2. Drug

    Clioquinol

    go.drugbank.com/drugs/DB04815
    ApprovedVet approvedWithdrawn

    Clioquinol was withdrawn in 1983 due to neurotoxicity.

    Mixtures: LOCACORTENE VİOFORME 0,2 MG/G+30 MG/G KREM, 30 G, LOCACORTENE VİOFORME 0,2 MG/G+30 MG/G KREM, 15 GSynonyms: 7-Iodo-5-chloroxine, 5-Chloro-7-iodo-8-quinolinol
  3. Drug

    Telitacicept

    go.drugbank.com/drugs/DB18312
    Investigational

    Synonyms: A,L121>E,G123>A,A216>S,P217>S)-TACI (TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR, TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY PROTEIN TNFRSF13B) HUMAN EXTRACELLULAR DOMAIN FRAGMENT (13-118)-PEPTIDE (1-106
  4. Drug

    Amifampridine

    go.drugbank.com/drugs/DB11640
    Approved

    About 50-60% of the patients develop more rapidly progressive LEMS and small cell lung cancer, which influences the prognosis [A33863]. … Firdapse (amifampridine) was formally approved by the US FDA for the treatment of adults with LEMS as recently as November of 2018 [L4819].

  5. Drug

    Pancrelipase lipase

    go.drugbank.com/drugs/DB13147
    ApprovedInvestigational

    [A32748] The pancrelipase mixture, including pancrelipase lipase, was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and FDA approved on April 12, 2010.[L2510]

    Mixtures: Pancrease Mt 10, Creon 10 Minimicrospheres
  6. Drug

    Honey

    go.drugbank.com/drugs/DB14242
    ApprovedInvestigational

    Honey is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

    Synonyms: Feng MiMixtures: Gongjinhyang Mi Luxury Base, Medi DP Energy Bar
  7. Target

    Heat shock protein 105 kDa

    go.drugbank.com/bio_entities/BE0009029
    TargetHumans

    Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured ...

    Polypeptides: Heat shock protein 105 kDa
  8. Target

    Tumor susceptibility gene 101 protein

    go.drugbank.com/bio_entities/BE0019070
    TargetHumans

    Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the assoc...

    Polypeptides: Tumor susceptibility gene 101 protein
  9. Drug

    Futibatinib

    go.drugbank.com/drugs/DB15149
    ApprovedInvestigational

    FGFR was investigated in oncology as a therapeutic target, as FGFR genomic aberrations and dysregulated FGFR signalling pathways are observed in some cancers such as cholangiocarcinoma and urothelial malignancies … [A253193,A253198] As a novel inhibitor of FGFR, futibatinib was first approved by the FDA in September 2022 to treat different types of intrahepatic cholangiocarcinoma.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates
  10. Drug

    Amlexanox

    go.drugbank.com/drugs/DB01025
    ApprovedWithdrawn

    Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population. … Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers.

    Synonyms: 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid