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Efgartigimod alfa
go.drugbank.com/drugs/DB15270ApprovedInvestigationalMyasthenia gravis (MG) is an autoimmune disorder characterized by significant muscle weakness - particularly in the eye, throat, and extremities - caused by autoantibodies attacking the neuromuscular junction … and a reduction in electrical nerve impulses.
Categories: Antineoplastic and Immunomodulating AgentsOdesivimab
go.drugbank.com/drugs/DB15900ApprovedInvestigationalINMAZEB™ is produced by Regeneron Pharmaceuticals and was granted FDA approval on October 14, 2020.[L17320] … All three mAbs bind to a distinct portion of the GP<sub>1,2</sub> glycoprotein and collectively provide neutralizing and Fc-mediated immune effector function against EBOV _in vitro_ and protection against
Categories: Amino Acids, Peptides, and ProteinsPrussian blue
go.drugbank.com/drugs/DB06783ApprovedIt is insoluble in water but also tends to form a colloid thus can exist in either colloidal or water-soluble form, and an insoluble form. … It is orally administered for clinical purposes to be used as an antidote for certain kinds of heavy metal poisoning, such as thallium and radioactive isotopes of caesium.
Avacincaptad pegol
go.drugbank.com/drugs/DB15165ApprovedInvestigationalThis approval is based on the positive results obtained from 2 phase 3 clinical trials GATHER1 and GATHER2.[L47701] … It was developed to treat an advanced form of age-related macular degeneration (AMD) called geographic atrophy (GA).
Categories: Nucleic Acids, Nucleotides, and NucleosidesDaprodustat
go.drugbank.com/drugs/DB11682ApprovedInvestigationalAs a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces erythropoiesis. … anemia of CKD but not for non-dialysis patients with anemia of CKD.
Categories: Blood and Blood Forming Organs, Amino Acids, Peptides, and ProteinsCariprazine
go.drugbank.com/drugs/DB06016ApprovedInvestigationalCariprazine gained its first global approval in the US in September 2015 [A3941] and was later approved by Health Canada in April 2022. … Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary.
Benralizumab
go.drugbank.com/drugs/DB12023ApprovedInvestigational[A31293] Benralizumab was FDA approved on November 14, 2017, and was developed by MedImmune, AstraZeneca's global biologic research and development arm.[L1019] … It is an afucosylated IgG which gives it high affinity for the FcγRIIIα receptor in natural killer cells, macrophages and neutrophils.
Categories: Amino Acids, Peptides, and ProteinsProducts: Fasenra 30mg Solution for Injection in Pre-filled Pen, FASENRA SOLUTION FOR INJECTION 30MG/ML (AUTOINJECTOR PEN)Zinc transporter ZIP10
go.drugbank.com/bio_entities/BE0009884TransporterHumansPlays an important for both mature B-cell maintenance and humoral immune responses (By similarity). … When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity)
Synonyms: Zrt- and Irt-like protein 10Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
go.drugbank.com/conditions/DBCOND0080506Drugs: Polatuzumab vedotinSynonyms: Malignant lymphoma, large cell, cleaved and noncleaved, Malignant lymphoma - large cell cleaved and non-cleavedTechnetium Tc-99m sestamibi
go.drugbank.com/drugs/DB09161ApprovedInvestigationalFollowing intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by the myocardium, parathyroid, and/or breast tissue. … infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.
Categories: Indicators and Reagents