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Displaying results 251 - 260 of 10000 in total
  1. Drug

    Promethazine

    go.drugbank.com/drugs/DB01069
    ApprovedInvestigational

    Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. … [A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.

    Mixtures: Promethazine and Phenylephrine HCl, and Codeine Phosphate, Meperidine Hcl and Promethazine HclCategories: prednisolone and promethazine, Miscellaneous Anxiolytics Sedatives and Hypnotics
  2. Drug

    Succinylcholine

    go.drugbank.com/drugs/DB00202
    ApprovedInvestigational

    Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short … [A19054] It has been widely used for over 50 years,[A299] most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures.

    Synonyms: 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)Products: Anectine Inj 20mg/ml, Quelicin Inj 20mg/ml USP
  3. Drug

    Pegvorhyaluronidase alfa

    go.drugbank.com/drugs/DB14912
    Investigational

    Pegvorhyaluronidase alfa is under investigation in clinical trial NCT02241187 (Two Stage Study Of Single Dose PEGPH20 And Cetuximab In Patients With Pancreatic Adenocarcinoma Prior To Surgical Resection

    Synonyms: ALFA, SUBSTITUTED ON N6 OF AN AVERAGE OF 4 TO, HUMAN HYALURONIDASE PH-20 (HYALURONOGLUCOSAMINIDASE PH-20, SPERM ADHESION MOLECULE 1, EC 3.2.1.35) PRECURSOR-(36-482)-PEPTIDE (MATURE (1-447)-PEPTIDE), PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, GLYCOFORMCategories: Enzymes and Coenzymes
  4. Drug

    Methotrimeprazine

    go.drugbank.com/drugs/DB01403
    Approved

    A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. … It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine.

    Synonyms: (-)-(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amineProducts: LEVOMEPROMAZIN-NEURAX 10MG, NEUROCIL 100MG
  5. Drug

    Bethanechol

    go.drugbank.com/drugs/DB01019
    Approved

    An advantage of bethanechol is that in contrast to acetylcholine, bethanechol is not degraded by cholinesterase allowing its effects to be longer-lasting.[L32539] … [A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous

    Synonyms: 2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminiumProducts: Urecholine Inj 5mg/ml, Urecholine Tab 10mg
  6. Drug

    Acetylsalicylic acid

    go.drugbank.com/drugs/DB00945
    ApprovedInvestigationalVet approved

    This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. … Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations

    Mixtures: TRINOMIA HARD CAPSULES 100mg/ 20mg/ 5mg, TRINOMIA HARD CAPSULES 100mg/ 20mg/ 10mgCategories: Alimentary Tract and Metabolism, Blood and Blood Forming Organs
  7. Drug

    Pacmilimab

    go.drugbank.com/drugs/DB18873
    Investigational

    Pacmilimab is under investigation in clinical trial NCT04596150 (Study to Evaluate the Safety and Antitumor Activity of CX-2009 Monotherapy and in Combination With CX-072 in Advanced Breast Cancer).

    Synonyms: IMMUNOGLOBULIN G4, ANTI-(HUMAN PROGRAMMED CELL DEATH-LIGAND 1) (HUMAN MONOCLONAL CX-072 .GAMMA.4-CHAIN), DISULFIDE WITH PRODOMAIN PROTEIN (SYNTHETIC MASKING MOIETY AND CLEAVABLE MOIETY PROTEASE SUBSTRATE-CONTAINING
  8. Drug

    Metoprolol

    go.drugbank.com/drugs/DB00264
    ApprovedInvestigational

    [A175162] Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.[L5527] … [T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.

    Mixtures: IMPLICOR 25MG/5MG FILM-COATED TABLETS, IMPLICOR 50MG/5MG FILM-COATED TABLETSCategories: metoprolol and thiazides, metoprolol and felodipine
  9. Drug

    Pseudoephedrine

    go.drugbank.com/drugs/DB00852
    Approved

    Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system. … [A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889.

    Mixtures: IBUCOLD PLUS 100MG+15MG+1MG/5ML ŞURUP, 100 ML SISE, BENICAL 10 MG+20MG+2MG/5 ML SURUP, 100 MLCategories: Alpha-and Beta-adrenergic Agonists
  10. Drug

    Naproxen

    go.drugbank.com/drugs/DB00788
    ApprovedInvestigationalVet approved

    [A178975] It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile. … Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994.

    Mixtures: VIMOVO 500MG/20MG MODIFIED-RELEASE TABLETS, Up and Up Sinus and Cold DCategories: naproxen and misoprostol, sumatriptan and naproxen