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Oritavancin
go.drugbank.com/drugs/DB04911ApprovedInvestigationalOritavancin is a glycopeptide antibiotic used for the treatment of skin infections. It was developed by The Medicines Company (acquired by Novartis). Oritavancin was initially approved by the FDA in 2014 and formulated to combat suscepti...
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP2C19 InhibitorsPermethrin
go.drugbank.com/drugs/DB04930ApprovedInvestigationalA pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersProducts: Kwellada-P Lotion, Kwellada-P CRème RinseBelinostat
go.drugbank.com/drugs/DB05015ApprovedInvestigationalBelinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety ...
Synonyms: (2E)-N-HYDROXY-3-(3-(PHENYLSULFAMOYL)PHENYL)PROP-2-ENAMIDE, N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamideCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesPretomanid
go.drugbank.com/drugs/DB05154ApprovedInvestigationalPersistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern. Research in recent years has been geared toward the development of novel therapies that target p...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesStaurosporine
go.drugbank.com/drugs/DB02010ExperimentalAn indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
Categories: P-glycoprotein inhibitorsTridolgosir
go.drugbank.com/drugs/DB02034ExperimentalAn indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.
Xanthine
go.drugbank.com/drugs/DB02134InvestigationalA purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xa...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesPlatelet Activating Factor
go.drugbank.com/drugs/DB02261ExperimentalCategories: P-glycoprotein inducers, P-glycoprotein substratesCytidine-5'-Monophosphate-5-N-Acetylneuraminic Acid
go.drugbank.com/drugs/DB02485ExperimentalA nucleoside monophosphate sugar which donates N-acetylneuraminic acid to the terminal sugar of a ganglioside or glycoprotein. [PubChem]
Synonyms: Cytidine-5'-Monophosphate-5-N-Acetylneuraminic AcidColforsin
go.drugbank.com/drugs/DB02587InvestigationalPotent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also...
Categories: P-glycoprotein inhibitors