Permethrin is an insecticide used to prevent infestation with Sarcoptes scabiei (scabies). A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies.
- Mechanism
- Curator reviewed
Permethrin acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance.
- Primary indication
- For the treatment of infestation with Sarcoptes scabiei (scabies).Curator reviewed · 4 structured indications
- Formula / weight
- C21H20Cl2O3 · 391.288 g/mol (avg)
- First approval
- Canada, 2003 · United States, 1989
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
RLLPVAHGXHCWKJ-UHFFFAOYSA-NSMILESCC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC(OC2=CC=CC=C2)=CC=C1What you can answer from here — as of September 23, 2026
3Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Permethrin, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account