Search

Displaying results 2591 - 2600 of 10000 in total
  1. Drug

    Etrasimod

    go.drugbank.com/drugs/DB14766
    ApprovedInvestigational

    2-mg daily dose regimen of etrasimod, with a 32% and 26% remission rate observed in UC 52 and UC 12 trials respectively. … Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P<sub>1,4,5</sub> with no detectable activity on S1P<sub>2</sub> and S1P<sub>3</sub

  2. Drug

    Floxuridine

    go.drugbank.com/drugs/DB00322
    ApprovedInvestigational

    Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution.

    Categories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index
  3. Drug

    SI-109

    go.drugbank.com/drugs/DB32603
    Experimental

    SI-109 is a potent, small-molecule inhibitor of the STAT3 SH2 domain.[A275443]

  4. Drug

    CPO-107

    go.drugbank.com/drugs/DB18492
    Investigational

    CPO-107 is a CD20-CD47 bispecific fusion protein

  5. Drug

    AMG-337

    go.drugbank.com/drugs/DB15639
    Investigational

    AMG-337 is under investigation in clinical trial NCT03147976 (QUILT-3.036: AMG 337 in Subjects With Advanced or Metastatic Solid Tumors).

  6. Drug

    TAS-108

    go.drugbank.com/drugs/DB05966
    Investigational

  7. Target

    Carcinoembryonic antigens

    go.drugbank.com/bio_entities/BE0010243
    Target

    Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis...

    Synonyms: Meconium antigen 100
  8. Drug

    Acetrizoic acid

    go.drugbank.com/drugs/DB09347
    ApprovedWithdrawn

    [L1704] Acetrizoic acid presents, in the FDA records, a category of drug substance with an inactive status.[L1703] … [A32135] It was first synthesized by Wallingford in 1953[A32136] and it was filled in the FDA by the Johnson & Johnson subsidiary, Cilag Chemie AG, on February 8th, 1978.

    Categories: Compounds used in a research, industrial, or household setting
  9. Drug

    Suzetrigine

    go.drugbank.com/drugs/DB18927
    ApprovedInvestigational

    Suzetrigine is a Na<sub>V</sub>1.8 voltage-gated sodium channel blocker with analgesic properties[A264948] Na<sub>V</sub>1.8 is abundantly expressed in peripheral sensory nerves to play a role in pain … signal transmission, making it a desirable therapeutic target for treatment of pain.

  10. Drug

    Axatilimab

    go.drugbank.com/drugs/DB16388
    ApprovedInvestigational

    Axatilimab is a humanized IgG4 monoclonal antibody produced in Chinese hamster ovary cells. … [L51194] It is targeted against macrophage colony-stimulating factor 1 receptor (CSF-1R), causing a reduction in circulating levels of monocytes and macrophages responsible for the symptoms associated