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Omega-3-carboxylic acids
go.drugbank.com/drugs/DB09568ApprovedWithdrawn[A25808] It was developed by AstraZeneca Pharmaceuticals and firstly approved by the FDA on May 05, 2014.[L2386] … The rest of the concentration is represented by docosapentaenoic acid and traces of some other components such as alpha-tocopherol, gelatin, glycerol, sorbitol and purified water.
Cariprazine
go.drugbank.com/drugs/DB06016ApprovedInvestigationalCariprazine gained its first global approval in the US in September 2015 [A3941] and was later approved by Health Canada in April 2022. … Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary.
RNA-splicing ligase RTCB
go.drugbank.com/bio_entities/BE0004442TargetHumansThese exon ends are then recognized and ligated by RTCB. … The ligation reaction, which requires guanosine triphosphate (GTP) and Mn(2+), proceeds through three metal-dependent steps.
Synonyms: RNA 2',3'-cyclic phosphate and 5'-OH ligaseAtoltivimab
go.drugbank.com/drugs/DB15898ApprovedInvestigationalINMAZEB™ is produced by Regeneron Pharmaceuticals and was granted FDA approval on October 14, 2020.[L17320] … All three mAbs bind to a distinct portion of the GP<sub>1,2</sub> glycoprotein and collectively provide neutralizing and Fc-mediated immune effector function against EBOV _in vitro_ and protection against
Categories: Amino Acids, Peptides, and ProteinsUbrogepant
go.drugbank.com/drugs/DB15328ApprovedInvestigational[L10959] Several oral small molecule CGRP receptor antagonists, belonging to a class of medications referred to as "gepants", have been investigated for migraines, but only ubrogepant and [rimegepant] … [L10926] It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine.
Trypsin
go.drugbank.com/drugs/DB11237ApprovedInvestigationalVet approvedThis nucleophilic attack is facilitated by the catalytic triad consisting of histidine-57, aspartate-102, and serine-195. … Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in digestion when administered orally.
Categories: Enzymes and Coenzymes, Blood and Blood Forming OrgansHelium
go.drugbank.com/drugs/DB09155ApprovedInvestigationalVet approvedIts boiling and melting points are the lowest among all the elements. Its clinical benefit in inhalation therapy arises from its advantageous physical properties than ambient air. … Helium is a second most abundant chemical element in the universe with symbol He and atomic number 2.
Ubiquinol
go.drugbank.com/drugs/DB11340ApprovedInvestigationalIt plays an essential role in maintaining cellular defense against oxidative damage and also sustains the effects of vitamin E by regenerating the vitamin from the tocopheroxyl radical, but ubiquinol is … Ubiquinol (CoQH2) is a reduced form of coenzyme Q10 (CoQ10) that acts as an active antioxidant that prevents the initiation and propagation of lipid peroxidation in biological membranes and human low-density
Categories: Enzymes and CoenzymesL-Acetylleucine
go.drugbank.com/drugs/DB16956ApprovedInvestigationalDL-) form has been available in France since 1957 for the treatment of vertigo. … [A264439] Observational studies in patients with Niemann-Pick disease type C (NPC) suggested a beneficial symptomatic as well as neuroprotective disease-modifying effect of the DL-form of N-acetylleucine
Categories: Amino Acids, Peptides, and ProteinsGepotidacin
go.drugbank.com/drugs/DB12134ApprovedInvestigational[ciprofloxacin] - while being structurally and pharmacologically distinct. … Gepotidacin is a first-in-class triazaacenaphthylene antibacterial targeting bacterial DNA gyrase and topoisomerase IV.[L52685] Its target is similar to that of fluoroquinolone antibacterials - e.g.