Search

Displaying results 2601 - 2610 of 2743 in total
  1. Drug

    Benzylthiouracil

    go.drugbank.com/drugs/DB13804
    Experimental

    Categories: Sex Hormones and Insulins
  2. Target

    Cyclin-dependent kinase 9

    go.drugbank.com/bio_entities/BE0002207
    TargetHumans

    In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6 (PubMed:20493174). Promotes cardiac myocyte enlargement (PubMed:20081228). … Also catalyzes phosphorylation of histone H1.4 (H1-4) at 'Ser-187' (H1.4S187Ph), a modification associated with transcription activation (PubMed:28539972).

    Synonyms: Tat-associated kinase complex catalytic subunit
  3. Target

    Proteasome subunit beta type-5

    go.drugbank.com/bio_entities/BE0002348
    TargetHumans

    Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity … Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.

    Synonyms: Multicatalytic endopeptidase complex epsilon chain
  4. Drug

    Lobeline

    go.drugbank.com/drugs/DB05137
    Investigational

    An alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, a...

  5. Drug

    Ormeloxifene

    go.drugbank.com/drugs/DB13310
    Experimental

    Ormeloxifene is a third-generation selective estrogen receptor (ER) modulator. In India, ormeloxifene has been marketed since the 1990s as a non-hormonal, non-steroidal oral contraceptive taken once a week, and it was later introduced fo...

    Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System
  6. Drug

    Lusutrombopag

    go.drugbank.com/drugs/DB13125
    ApprovedInvestigational

    Lusutrombopag binds to the transmembrane domain of TPOR expressed on megakaryocytes, and causes the proliferation and differentiation of megakaryocytic progenitor cells from hematopoietic stem cells [FDA … Higher percentages (65-78%) of the patients receiving lusutrombopag required no platelet transfusion prior to the primary invasive procedure compared to those receiving placebo [L4166].

  7. Target

    Proteasome subunit beta type-4

    go.drugbank.com/bio_entities/BE0003918
    TargetHumans

    Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

    Synonyms: Multicatalytic endopeptidase complex beta chain
  8. Drug

    Sulfatolamide

    go.drugbank.com/drugs/DB13547
    Experimental

    Categories: Genito Urinary System and Sex Hormones
  9. Drug

    Tamsulosin

    go.drugbank.com/drugs/DB00706
    ApprovedInvestigational

    Tamsulosin is a selective alpha-1A and alpha-1B adrenoceptor antagonist that exerts its greatest effect in the prostate and bladder, where these receptors are most common.[Label] It is indicated for the treatment of signs and symptoms of...

    Mixtures: Aglandin comp. 0,5 mg/0,4 mg-Hartkapseln, Dutaglandin comp. 0,5 mg/0,4 mg-HartkapselnCategories: Genito Urinary System and Sex Hormones
  10. Drug

    Fedratinib

    go.drugbank.com/drugs/DB12500
    ApprovedInvestigational

    Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis. It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval o...

    Categories: Genito Urinary System and Sex Hormones