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Displaying results 2611 - 2620 of 10000 in total
  1. Drug

    PA-1050040

    go.drugbank.com/drugs/DB06039
    Experimental

    It inhibits virus replication by the same mechanism of action as BVM.

  2. Drug

    Etryptamine

    go.drugbank.com/drugs/DB01546
    ApprovedIllicitWithdrawn

    In the 1960's, alpha-ethyltryptamine (αET), a non hydrazine reversible monoamine oxidase inhibitor, was developed in the United States by the Upjohn chemical company for use as an antidepressant. αET was … αET is a stimulant and hallucinogen, but it is less stimulating and hallucinogenic than alpha-methyltryptamine, a closely related compound.

  3. Drug

    Filgotinib

    go.drugbank.com/drugs/DB14845
    ApprovedInvestigational

    [A189165] Non-selective JAK inhibitors like [tofacitinib] target JAK1 and JAK3 subtypes with minimal activity at JAK2. In contrast, the newly approved filgotinib is a highly selective JAK1 inhibitor. … [A189165] New therapeutic developments target other inflammatory pathways implicated in RA including the Janus kinase (JAK) signaling pathway as seen with filgotinib.

  4. Drug

    Milrinone

    go.drugbank.com/drugs/DB00235
    ApprovedInvestigational

    [A228333] It was approved by the FDA on December 31, 1987, and was marketed under the trademark PRIMACOR® by Sanofi-Aventis US before being discontinued.[L31483] … Heart failure is underpinned by numerous physiological changes, including alteration in β-adrenergic signalling and cyclic adenosine monophosphate (cAMP) production, which affects the heart's contractile

  5. Drug

    Felodipine

    go.drugbank.com/drugs/DB01023
    Approved

    It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. … By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction.

    Products: FELODIPIN 2.5MG RET HEU N
  6. Target

    Sodium-dependent dopamine transporter

    go.drugbank.com/bio_entities/BE0000647
    TargetTransporterHumans

    Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:11093780, PubMed:1406597, PubMed:15505207, PubMed:19478460, PubMed:39112701, PubMed:39112703, PubMed:39112705, PubMed:8302271). Also mediates sodium- ...

    Synonyms: DAT, DA transporter
  7. Drug

    Nisoxetine

    go.drugbank.com/drugs/DB09186
    Experimental

    It was originally investigated as an antidepressant but has no current clinical applications aside from being a research standard SNRI. … It has been used to research obesity and energy balance, and exerts some local analgesia effects.

  8. Indication

    Advanced Non-Small Cell Lung Cancer (NSCLC)

    go.drugbank.com/conditions/DBCOND0067310
    Drugs: Almonertinib · Amivantamab · Carboplatin · Hu-rhEGF-rP64k/Mont · Lazertinib · Lorlatinib +2 more
    Synonyms: Advanced Non-Small Cell Lung Cancer, Advanced Stage Non-small Cell Lung Cancer
  9. Indication

    Completely obstructive Non-Small Cell Lung Cancer

    go.drugbank.com/conditions/DBCOND0022196
    Drugs: Porfimer sodium
    Synonyms: Completely obstructive Non-Small Cell Lung Cancer
  10. Indication

    Relapsed Low Grade Non-Hodgkin's Lymphoma (NHL)

    go.drugbank.com/conditions/DBCOND0145175
    Drugs: Rituximab
    Synonyms: Relapsed Low Grade Non-Hodgkin's Lymphoma (NHL)