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Sarecycline
go.drugbank.com/drugs/DB12035ApprovedInvestigationals Seysara (sarecylcine) as a new first in class narrow spectrum tetracycline derived oral antibiotic for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients … The acne often presents physically as a mixture of non-inflammatory and inflammatory lesions mainly on the face but on the back and chest as well [L4814].
Categories: P-glycoprotein inhibitorsPrimaquine
go.drugbank.com/drugs/DB01087ApprovedInvestigationalIt has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. … An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 6-Methoxy-8-(4-amino-1-methylbutylamino)quinoline, 8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinolineOteseconazole
go.drugbank.com/drugs/DB13055ApprovedInvestigational[L41635] CYP51, also known as 14α demethylase, participates in the formation of ergosterol, a compound that plays a vital role in the integrity of cell membranes. … [A247035] This is possible thanks to the tetrazole moiety in oteseconazole that increases target selectivity.
Synonyms: (R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol, 2-Pyridineethanol, α-(2,4difluorophenyl)-β β-difluoro- α-(1H-tetrazol-1-ylmethyl)-5-(4-(2,2,2-trifluoroethoxy)phenyl)-,(αR)Categories: Heterocyclic Compounds, 1-RingInsulin aspart
go.drugbank.com/drugs/DB01306ApprovedInvestigationalInsulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. … Insulin is an important treatment in the management of Type 1 Diabetes (T1D) which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able
Mixtures: Ryzodeg® FlexTouch® 100 U/ml Solution for Injection, RYZODEG PENFİLL 100 U/ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KARTUŞ, 5 ADETCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersPenbutolol
go.drugbank.com/drugs/DB01359ApprovedInvestigationalWithdrawnPenbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. … Penbutolol also demonstrates high binding affinity to the 5-hydroxytryptamine receptor 1A with antagonistic effects.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesSynonyms: (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-olCeritinib
go.drugbank.com/drugs/DB09063ApprovedInvestigationalThis occurrence led to development of novel second-generation ALK inhibitors such as ceritinib to overcome crizotinib resistance. … Following treatment with crizotinib (a first-generation ALK inhibitor), most tumours develop drug resistance due to mutations in key "gatekeeper" residues of the enzyme.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propane-2-sulfonamidePolyethylene glycol 300
go.drugbank.com/drugs/DB11161ApprovedPEG 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of the eyes. … They serve as solubilizers, excipients, lubricants, and chemical reagents. Low molecular weight glycols are observed to exhibit antibacterial properties as well.
Categories: P-glycoprotein inhibitors, Compounds used in a research, industrial, or household settingSynonyms: PEG-6Flutemetamol (18F)
go.drugbank.com/drugs/DB09151ApprovedInvestigationalFlutemetamol (18F), an analogue of [(11)C]PIB,[A18519] is a radioactive diagnostic drug used for Positron Emission Tomography (PET) imaging of the brain to estimate β amyloid neuritic plaque density. … It is used to evaluate Alzheimer's disease (AD) or other causes of cognitive decline as an Aβ-specific positron emission tomography (PET) ligand.[L35029]
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: 2-[3-(18F)fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol, 2-[3-[18F]fluoro-4-(methylamino) phenyl]-6-benzothiazololBepridil
go.drugbank.com/drugs/DB01244ApprovedWithdrawnIt is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias (ie. Torsade de pointes). … A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects.
Synonyms: 1-(2-(N-BENZYLANILINO)-1-(ISOBUTOXYMETHYL)ETHYL)-PYRROLIDINE, 1-PYRROLIDENEETHANAMINE, .BETA.-((2-METHYLPROPOXY)METHYL)-N-PHENYL-N-(PHENYLMETHYL)-Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesNaldemedine
go.drugbank.com/drugs/DB11691ApprovedInvestigationalIt is a modified form of [DB00704] to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. … Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opioid-induced Constipation.
Categories: Heterocyclic Compounds with 4 or More Rings