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Displaying results 2661 - 2670 of 5900 in total
  1. Drug

    Carbidopa

    go.drugbank.com/drugs/DB00190
    ApprovedInvestigational

    Due to its activity, carbidopa is always administered concomitantly with [levodopa]. … It potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does not cross the blood-brain barrier.

  2. Drug

    Osimertinib

    go.drugbank.com/drugs/DB09330
    ApprovedInvestigational

    Approximately 10% of patients with NSCLC have a rapid and clinically effective response to EGFR-TKIs due to the presence of specific activating EGFR mutations within the tumour cells. … [A7927] More specifically, deletions around the LREA motif in exon 19 and exon 21 L858R point mutations are correlated with response to therapy.

  3. Drug

    Acetohexamide

    go.drugbank.com/drugs/DB00414
    ApprovedWithdrawn

    A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.

  4. Drug

    Diflorasone

    go.drugbank.com/drugs/DB00223
    Approved

    Diflorasone is a topical corticosteroid used to treat itching and inflammation of the skin.

  5. Drug

    Mezlocillin

    go.drugbank.com/drugs/DB00948
    Approved

    Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections.

  6. Drug

    Labetuzumab

    go.drugbank.com/drugs/DB05097
    Investigational

    Labetuzumab is a humanized monoclonal antibody to carcinoembryonic antigen that inhibits tumor growth. It is used in radioimmunotherapy.

    Synonyms: MN14 monoclonal antibody to carcinoembryonic antigen
  7. Drug

    WL-1002

    go.drugbank.com/drugs/DB05346
    Experimental

    WL-1002 is developed by Winston Laboratories which is a topical cream formulation of 075% zucapaicin (also known as civamide), for the treatment of pain due to osteoarthritis.

  8. Drug

    Botulinum toxin type B

    go.drugbank.com/drugs/DB00042
    Approved

    Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex. The neurotoxin complex is recovered from the fer...

  9. Drug

    Elbasvir

    go.drugbank.com/drugs/DB11574
    Approved

    [A19593] Substitutions at amino acid positions 28, 30, 31, or 93 are known to confer resistance to elbasvir. … [synthesis] The barrier to the development of resistance to NS5A inhibitors is lower than that of NS5B inhibitors, another class of DAAs.

  10. Drug

    Sodium cellulose phosphate

    go.drugbank.com/drugs/DB06776
    Approved

    Sodium cellulose phosphate is used to treat hypercalcemia and hypercalciuria. It has been used to prevent kidney stones. … However, it can be used to restore normal intestinal calcium absorption.