Diflorasone is a topical corticosteroid used to treat the symptoms of various inflammatory skin conditions that cause erythema, pruritus, and discomfort.
- Mechanism
- Curator reviewed
The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
- Primary indication
- For relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.Curator reviewed · 1 structured indication
- Formula / weight
- C22H28F2O5 · 410.4515 g/mol (avg)
- First approval
- Canada, 1980 · United States, 1985
- Brand names
Resolves to
WXURHACBFYSXBI-XHIJKXOTSA-NSMILES[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12CWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Diflorasone, and which of those have an active Phase 3 trial?
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