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Displaying results 2661 - 2670 of 10000 in total
  1. Drug

    Sipuleucel-T

    go.drugbank.com/drugs/DB06688
    ApprovedInvestigational

    Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. … The treatment initially cost $93,000 at the time of FDA approval, but rose to over $100,000 in 2014.

  2. Target

    Nitric oxide synthase oxygenase

    go.drugbank.com/bio_entities/BE0001483
    TargetStaphylococcus aureus (strain MW2)

    Catalyzes the production of nitric oxide.

    Synonyms: SANOS
  3. Drug

    Rolapitant

    go.drugbank.com/drugs/DB09291
    ApprovedInvestigational

    late-phase CINV during the first 120 hours post-chemotherapy. … Unlike other available NK-1 receptor antagonists, rolapitant is not an inhibitor of Cytochrome P450 enzyme CYP3A4 and has a long elimination half-life, allowing a single dose to prevent both acute and

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Inhibitors
  4. Drug

    Demeclocycline

    go.drugbank.com/drugs/DB00618
    Approved

    A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

  5. Drug

    Norelgestromin

    go.drugbank.com/drugs/DB06713
    ApprovedInvestigational

    Norelgestromin is a progestin used as the progestational component of combined hormonal contraceptives. … Norelgestromin was first approved in the United States in 2001 as the progestin in a norelgestromin and ethinyl estradiol transdermal contraceptive system.[L63816]

    Mixtures: EVRA TRANSDERMAL PATCH (6 mg/600 mcg)Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  6. Drug

    Profenamine

    go.drugbank.com/drugs/DB00392
    Approved

    Profenamine (also known as ethopropazine) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat Parkinsonism.

    Synonyms: 10-(2-diethylaminopropyl)phenothiazine, 10-[2-(diethylamino)propyl]phenothiazineProducts: Parsitan 50
  7. Drug

    Diphemanil

    go.drugbank.com/drugs/DB13720
    ApprovedVet approvedWithdrawn

  8. Pathway

    Acylcarnitine (15Z)-tetracos-15-enoylcarnitine

    smpdb.ca/view/SMP0124424
    Metabolic

    (15Z)-tetracos-15-enoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, (15Z)-tetracos-15-enoyl-CoA reacts with L-carnitine to form (15Z)-tetracos-15-enoylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  9. Drug

    Cresol

    go.drugbank.com/drugs/DB11143
    Approved

    At concentrations normally found in the environment however, cresols do not pose any significant risk for the general population. … Cresol is a hydroxytoluene that can be extracted naturally from coal tar or made synthetically. Pure cresol is a mixture of ortho-, meta-, and para- isomers.

  10. Drug

    Toremifene

    go.drugbank.com/drugs/DB00539
    ApprovedInvestigational

    Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer.

    Mixtures: FLOBACT - D, FLOBACT - DCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors