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Betahistine
go.drugbank.com/drugs/DB06698ApprovedInvestigational[A220333,L16403] Betahistine was first approved by the FDA in the 1970s but withdrawn within approximately 5 years due to a lack of evidence supporting its efficacy. … It has a significant impact on both the physical and social functioning of affected individuals.
Synonyms: N-methyl-2-(2-pyridinyl)ethanamine, [2-(2-pyridyl)ethyl]methylamineCategories: Heterocyclic Compounds, 1-RingEsomeprazole
go.drugbank.com/drugs/DB00736ApprovedInvestigationalat the secretory surface of gastric parietal cells. … Esomeprazole is the s-isomer of [DB00338], which is a racemate of the S- and R-enantiomer.
Synonyms: (S)-omeprazole, (S)-(−)-omeprazoleInternational brands: ES-ODTopiramate
go.drugbank.com/drugs/DB00273ApprovedInvestigationalTopiramate is a anti-epileptic drug used to manage seizures and prevent migraines.[A175249] It was initially approved by the FDA in 1996. … [L10550] Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen.
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A InducersSynonyms: 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate, 2,3:4,5-di-O-isopropylidene-β-D-fructopyranose sulfamateImatinib
go.drugbank.com/drugs/DB00619ApprovedInvestigationalBrian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated with a daily dosage of 300 mg or more and typically occurred in the first four weeks of therapy". … [A249305] It was deemed a "miracle drug" due to its clinical success, as oncologist Dr.
Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein inhibitorsSynonyms: α-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidideAlprazolam
go.drugbank.com/drugs/DB00404ApprovedIllicitInvestigational[A18125] Alprazolam was given FDA approval on October 16, 1981.[L6148] … [A18125] Alprazolam's adverse effects are generally related to the sedation it can cause.
Mixtures: NEUPAX DUO-SCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingOxytocin
go.drugbank.com/drugs/DB00107ApprovedInvestigationalVet approved[A229108,A229113] It is estimated that labor induction with oxytocin is used in almost 10% of deliveries globally. … [A229008,A228593,A229108] Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues.
Mixtures: Bakumokon 5% Minoxidil, Bakumokon 7% Minoxidil SulfateProducts: PITOCIN 10 UNIDADES X ML. AMPOLLETAS, Oxytocin-Richter solution for injection 10 I.U / 1 mlLevonorgestrel
go.drugbank.com/drugs/DB00367ApprovedInvestigational[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. … It was initially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogenic adverse effects when compared
Mixtures: FemSevenCombi 50 Mikrogramm/10 Mikrogramm/24 Stunden - Depot-Pflaster, SERMELLA 10Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAphidicolin
go.drugbank.com/drugs/DB17742ExperimentalIt inhibits DNA polymerase alpha and blocks DNA replication.[A259157, A259162]
Synonyms: 9,15-cyclo-c,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3.alpha.,4.alpha.,5.alpha.,17.alpha.)-, 8,11a-methano-11ah-cyclohepta(a)naphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3r,4r,4ar,6as,8r,9r,11as,11bs)-Megestrol acetate
go.drugbank.com/drugs/DB00351ApprovedInvestigationalVet approved17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. … As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: MGA, 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetatePalonosetron
go.drugbank.com/drugs/DB00377ApprovedInvestigationalAs of 2008, it is the most recent 5-HT3 antagonist to enter clinical use. … It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy and is the only drug of
Synonyms: 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one, (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-oneCategories: Serotonin 5-HT3 Receptor Antagonists, Antiemetic Serotonin 5-HT3 Receptor Antagonists