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Displaying results 261 - 270 of 10000 in total
  1. Drug

    Didanosine

    go.drugbank.com/drugs/DB00900
    ApprovedInvestigational

    A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. … Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative

    Categories: Heterocyclic Compounds, 2-Ring, Nucleic Acids, Nucleotides, and NucleosidesSynonyms: 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one, 9-((2S,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ol
  2. Drug

    Tegafur

    go.drugbank.com/drugs/DB09256
    ApprovedInvestigational

    Tegafur (INN, BAN, USAN) is a prodrug of [DB00544] (5-FU), an antineoplastic agent used as the treatment of various cancers such as advanced gastric and colorectal cancers. … When converted and bioactivated to 5-FU, the drug mediates an anticancer activity by inhibiting thymidylate synthase (TS) during the pyrimidine pathway involved in DNA synthesis. 5-FU is listed on the

    Mixtures: TS-ONE CAPSULE 20, TS-ONE CAPSULE 20Categories: Heterocyclic Compounds, 1-Ring, Fluorouracil and prodrugs
  3. Drug

    (10E,12Z)-octadecadienoic acid

    go.drugbank.com/drugs/DB04746
    Experimental

    Synonyms: 10-trans-12-cis-CLA, 10-trans-12-cis-linoleic acid
  4. Drug

    Trimipramine

    go.drugbank.com/drugs/DB00726
    ApprovedInvestigational

    Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.

    Categories: Adrenergic alpha-1 Receptor Antagonists, Serotonin 5-HT1 Receptor AntagonistsSynonyms: 10,11-dihydro-N,N,β-trimethyl-5H-dibenz[b,f]azepine-5-propanamine, 5-(γ-dimethylamino-β-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
  5. Drug

    Diazepam

    go.drugbank.com/drugs/DB00829
    ApprovedIllicitInvestigationalVet approved

    A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. … It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal

    Mixtures: Gabavale-5Categories: Hypnotics and Sedatives, Benzodiazepine hypnotics and sedatives
  6. Drug

    Zoxazolamine

    go.drugbank.com/drugs/DB19372
    ApprovedWithdrawn

    Synonyms: 2-amino-5-chlorobenzoxazole, 5-chloro-2-benzoxazolamineCategories: Benzoxazoles and derivatives, Heterocyclic Compounds, 2-Ring
  7. Drug

    Benoxaprofen

    go.drugbank.com/drugs/DB04812
    ApprovedWithdrawn

    The holder of the approved application voluntarily withdrew Oraflex tablets from the market on August 5, 1982.

    Categories: Antiinflammatory and Antirheumatic Products, Antiinflammatory and Antirheumatic Products, Non-SteroidsSynonyms: (1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid, 2-(4-chlorophenyl)-α-methyl-5-benzoxazoleacetic acid
  8. Drug

    Decitabine

    go.drugbank.com/drugs/DB01262
    ApprovedInvestigational

    [A2263, A2264, A2265, A215317, L14962] Decitabine was developed by MGI Pharma/SuperGen Inc. and was approved by the FDA for the treatment of MDS on February 5, 2006. … Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying etiology and presentation, including neutropenia and thrombocytopenia.

    Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsSynonyms: 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one, 5-aza-2'-deoxycytidine
  9. Drug

    Linezolid

    go.drugbank.com/drugs/DB00601
    ApprovedInvestigational

    [A233425] A second member of this class, [tedizolid], was approved by the FDA in 2014 and is considered generally more effective and tolerable than its predecessor. … Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria.

    Categories: Heterocyclic Compounds, 1-Ring, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesSynonyms: N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide
  10. Drug

    Entacapone

    go.drugbank.com/drugs/DB00494
    ApprovedInvestigational

    of levodopa and a decarboxylase inhibitor. … When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa concentrations are reached as compared to the administration

    Mixtures: ANTIPAR 200 MG/50 MG/200 MG FILM KAPLI TABLET, 100 ADET, ANTIPAR 50 MG/ 12,5 MG/ 200 MG FİLM KAPLI TABLET, 100 ADETCategories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme Inhibitors