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Displaying results 261 - 270 of 10000 in total
  1. Drug

    Etoposide

    go.drugbank.com/drugs/DB00773
    ApprovedInvestigational

    This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. … A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.

    Categories: Topoisomerase II Inhibitors, UGT1A1 Substrates with a Narrow Therapeutic IndexSynonyms: 4-demethylepipodophyllotoxin β-D-ethylideneglucoside, 9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one
  2. Target

    Melanoma antigen preferentially expressed in tumors

    go.drugbank.com/bio_entities/BE0010493
    TargetHumans

    In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin

    Polypeptides: Melanoma antigen preferentially expressed in tumors
  3. Drug

    Hydrogenated soybean oil

    go.drugbank.com/drugs/DB11302
    Approved

    Extracted from the seeds of the soybean (Glycine soja), hydrogenated soybean oil is a major food fat used in the production of margarine, shortening, and salad and cooking oils. … Linolenic acid and stearic acids are contained in hydrogenated soybean oil, but hydrogenation results in reduced unsaturation in linolenic acid.

    Products: S Balloon Slim Body Line
  4. Drug

    Icatibant

    go.drugbank.com/drugs/DB06196
    ApprovedInvestigational

    [A4017,A263046] Icatibant was approved by the FDA on August 25, 2011, and by the EMA in 2008 as a treatment for hereditary angioedema. … [A4017,A263041] It was investigated as a potential treatment of hereditary angioedema (HAE) as bradykinin was implicated in HAE swelling; specifically, mice lacking B<sub>2</sub> receptors showed reduced

    Categories: Drugs Used in Hereditary AngioedemaProducts: ICATIBANT DR. REDDY'S, Icatibant STADA 30 mg Injektionslösung in einer Fertigspritze
  5. Drug

    Magnesium hydroxide

    go.drugbank.com/drugs/DB09104
    ApprovedInvestigational

    Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. … It can also be used topically as a deodorant or for the relief of canker sores (aphthous ulcers).

    Mixtures: Maalox oral suspension in sachet, MULTIGEL IISynonyms: Hidroxido de magnesio
  6. Drug

    Esmolol

    go.drugbank.com/drugs/DB00187
    ApprovedInvestigationalWithdrawn

    It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. … Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker.

    Products: Esmolol Hydrochloride in Water, Esmolol Hydrochloride In Sodium Chloride
  7. Drug

    Ritodrine

    go.drugbank.com/drugs/DB00867
    ApprovedWithdrawn

    Adrenergic beta-agonist used to control premature labor.

    Products: PRE-PAR 50 MG/5 ML IM/IV ÇÖZELTİ İÇEREN AMPUL, 1 AMPUL, Yutopar Inj 50mg/5ml
  8. Drug

    Metoclopramide

    go.drugbank.com/drugs/DB01233
    ApprovedInvestigational

    Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. … It is available in the oral tablet form or in solution, and can also be administered through the intravenous route.[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922]

    Categories: Dopamine D2 Receptor AntagonistsSynonyms: 2-methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide
  9. Drug

    Selenium Sulfide

    go.drugbank.com/drugs/DB00971
    Approved

    Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent … Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea.

    Synonyms: Selenium(IV) sulfide, Selenium(IV) sulphideProducts: Selsun Blue 2-in-1, Selsun Blue, 2-IN-1
  10. Drug

    Methylprednisolone hemisuccinate

    go.drugbank.com/drugs/DB14644
    ApprovedInvestigational

    A water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.

    Categories: Compounds used in a research, industrial, or household settingProducts: SOLU-MEDROL DE 40 MG SOLUCION, A-methapred