Selenium Sulfide

Identification

Summary

Selenium Sulfide is an antifungal used to treat dandruff, seborrheic dermatitis of the scalp, and tinea capitis.

Brand Names
Selrx, Selsun Blue
Generic Name
Selenium Sulfide
DrugBank Accession Number
DB00971
Background

Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea. Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent children.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 143.09
Monoisotopic: 143.860663208
Chemical Formula
S2Se
Synonyms
  • Selenii disulfidum
  • Selenium disulfide
  • Selenium disulphide
  • Selenium Sulfide
  • Selenium sulfide, micronized
  • Selenium sulphide
  • Selenium sulphide, micronized
  • Selenium(IV) disulfide
  • Selenium(IV) disulphide
  • Selenium(IV) sulfide
  • Selenium(IV) sulphide

Pharmacology

Indication

For treatment of tinea versicolor, tinea capitis, dandruff and seborrheic dermatitis of the scalp.

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Selenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and seborrheic dermatitis. Selenium sulfide is highly active in inhibiting the growth of P. ovale. It is also a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis. A 0.6% micronized form of selenium sulfide is also safe and effective for dandruff.

Mechanism of action

Topical selenium sulfide may act by an antimitotic action, resulting in a reduction in the turnover of epidermal cells. It also has local irritant, antibacterial, and mild antifungal activity, which may contribute to its effectiveness. An antimitotic mechanism of action is suggested by data showing that selenium sulfide decreases the rate of incorporation of radioactively labeled thymidine into the DNA of dermal epithelial cells. The following organisms are generally considered susceptible to selenium sulfide in vitro: Malassezia furfur, Microsporum sp. including Microsporum audouinii and Microsporum canis, Pityrosporon sp., Trichophyton sp. including Trichophyton schoenleinii and Trichophyton tonsurans. Selenium sulfide has been shown to be sporicidal to T. tonsurans, the most common etiologic agent of tinea capitis. One in-vitro study demonstrated that 2.5% selenium sulfide was equivalent in sporicidal activity to both 1% and 2% zinc pyrithione.

Absorption

There is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 μg/ml in her urine.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

No documented reports of serious toxicity in humans resulting from acute ingestion of selenium sulfide, however, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
No interactions found.
Food Interactions
No interactions found.

Products

Products2
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Active Moieties
NameKindUNIICASInChI Key
SeleniumunknownH6241UJ22B7782-49-2BUGBHKTXTAQXES-UHFFFAOYSA-N
International/Other Brands
Exsel Lotion Shampoo / Glo-Sel / Head & Shoulders Intensive Treatment / Versel Lotion
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Selenium SulfideShampoo22.5 mg/1mLTopicalRiver's Edge Pharmaceuticals, LLC2008-12-082012-10-31US flag
Selenium SulfideShampoo22.5 mg/1mLTopicalBi-Coastal Pharma International LLC2011-06-01Not applicableUS flag
Selenium SulfideShampoo22.5 mg/1mLTopicalMethod Pharmaceuticals, LLC2015-06-01Not applicableUS flag
Selenium SulfideShampoo22.5 mg/1mLTopicalNoble Pharmaceuticals, Llc2017-05-09Not applicableUS flag
Selenium SulfideShampoo22.5 mg/1mLTopicalKmm Pharmaceuticals, Llc2017-11-14Not applicableUS flag
Selenium SulfideShampoo22.5 mg/1mLTopicalRochester Pharmaceuticals2011-03-302019-07-08US flag
Selenium SulfideShampoo23 mg/1mLTopicalBowyn Labs, Llc2018-04-12Not applicableUS flag
Selenium SulfideShampoo23 mg/1mLTopicalMethod Pharmaceuticals, LLC2018-04-05Not applicableUS flag
Selenium SulfideShampoo23 mg/1mLTopicalCameron Pharmaceuticals, LLC2018-04-20Not applicableUS flag
Selenium SulfideShampoo22.5 mg/1mLTopicalAcella Pharmaceuticals, LLC2017-07-12Not applicableUS flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Selenium SulfideLotion2.5 g/100mLTopicalPhysicians Total Care, Inc.2006-09-25Not applicableUS flag
Selenium SulfideLotion2.5 mg/100mLTopicalA S Medication Solutions2006-09-25Not applicableUS flag
Selenium SulfideLotion25 mg/1mLTopicalCentral Texas Community Health Centers1983-09-01Not applicableUS flag
Selenium SulfideLotion2.5 mg/100mLTopicalA-S Medication Solutions2006-09-252017-05-31US flag
Selenium SulfideLotion25 mg/1mLTopicalA-S Medication Solutions1983-09-01Not applicableUS flag
Selenium SulfideLotion2.5 mg/100mLTopicalRpk Pharmaceuticals, Inc.2006-09-25Not applicableUS flag
Selenium SulfideLotion2.5 mg/100mLTopicalPerrigo New York Inc2006-09-25Not applicableUS flag
Selenium SulfideLotion25 mg/1mLTopicalMorton Grove Pharmaceuticals, Inc.1983-09-01Not applicableUS flag
Selenium SulfideLotion2.5 mg/100mLTopicalNucare Pharmaceuticals,inc.2006-09-25Not applicableUS flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Antidandruff MedicatedShampoo1.0000 mL/100mLTopicalCVS Health2010-07-06Not applicableUS flag
Antidandruff MedicatedShampoo1.0000 mL/100mLTopicalSafeway2010-08-05Not applicableUS flag
Care One MedicatedLiquid10 mg/1mLTopicalAmerican Sales Company2013-08-15Not applicableUS flag
Care One MoisturizingLiquid10 mg/1mLTopicalAmerican Sales Company2013-07-15Not applicableUS flag
Careone Medicated DandruffLiquid10 mg/1mLTopicalAmerican Sales Company2014-11-17Not applicableUS flag
Careone Medicated DandruffShampoo10 mg/1mLTopicalSpa Dent Inc2021-07-20Not applicableUS flag
Careone Medicated DandruffShampoo10 mg/1mLTopicalRetail Business Services, LLC2021-08-26Not applicableUS flag
CareOne Medicated Dandruff with MentholShampoo10 mg/1mLTopicalAmerican Sales Company2018-03-27Not applicableUS flag
Careone Moisturizing DandruffShampoo1 mL/100mLTopicalAmerican Sales Company2011-08-19Not applicableUS flag
Careone Moisturizing DandruffLiquid10 mg/1mLTopicalAmerican Sales Company2015-01-13Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Clease and TreatSelenium Sulfide (0.5 g/5g) + Benzoyl peroxide (0.8 g/5g)ClothTopicalQuinnova Pharmaceuticals, Inc.2009-01-01Not applicableUS flag
Selenium SulfideSelenium Sulfide (23 mg/1mL)ShampooTopicalLaser Pharmaceuticals, LLC2020-06-02Not applicableUS flag
Selenium SulfideSelenium Sulfide (22.5 mg/1mL)ShampooTopicalWestminster Pharmaceuticals2019-09-09Not applicableUS flag
Selenium SulfideSelenium Sulfide (23 mg/1mL)ShampooTopicalCameron Pharmaceuticals, LLC2018-04-20Not applicableUS flag
Selenium SulfideSelenium Sulfide (22.5 mg/1mL)ShampooTopicalAcella Pharmaceuticals, LLC2017-07-12Not applicableUS flag
Selenium SulfideSelenium Sulfide (22.5 mg/1mL)ShampooTopicalMethod Pharmaceuticals, LLC2015-06-01Not applicableUS flag
Selenium SulfideSelenium Sulfide (23 mg/1mL)ShampooTopicalbryant ranch prepack2018-04-05Not applicableUS flag
Selenium SulfideSelenium Sulfide (22.5 mg/1mL)ShampooTopicalbryant ranch prepack2017-05-09Not applicableUS flag
Selenium SulfideSelenium Sulfide (23 mg/1mL)ShampooTopicalMethod Pharmaceuticals, LLC2018-04-05Not applicableUS flag
Selenium SulfideSelenium Sulfide (22.5 mg/1mL)ShampooTopicalbryant ranch prepack2015-06-01Not applicableUS flag

Categories

ATC Codes
D01AE13 — Selenium sulfide
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as other non-metal sulfides. These are inorganic compounds containing a sulfur atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of other non-metals.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Other non-metal organides
Sub Class
Other non-metal sulfides
Direct Parent
Other non-metal sulfides
Alternative Parents
Inorganic sulfides
Substituents
Inorganic sulfide / Other non-metal sulfide
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
  • Humans and other mammals
  • Fungi
  • Bacteria

Chemical Identifiers

UNII
Z69D9E381Q
CAS number
7488-56-4
InChI Key
JNMWHTHYDQTDQZ-UHFFFAOYSA-N
InChI
InChI=1S/S2Se/c1-3-2
IUPAC Name
thione
SMILES
S=[Se]=S

References

General References
  1. Johnson BA, Nunley JR: Treatment of seborrheic dermatitis. Am Fam Physician. 2000 May 1;61(9):2703-10, 2713-4. [Article]
  2. Chen C, Koch LH, Dice JE, Dempsey KK, Moskowitz AB, Barnes-Eley ML, Hubbard TW, Williams JV: A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Pediatr Dermatol. 2010 Sep-Oct;27(5):459-62. doi: 10.1111/j.1525-1470.2010.01093.x. Epub 2010 Aug 24. [Article]
PubChem Compound
24087
PubChem Substance
46507535
ChemSpider
22519
RxNav
36345
ChEBI
135934
ChEMBL
CHEMBL1200680
PharmGKB
PA164771240
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
MSDS
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
Not AvailableCompletedTreatmentTinea Capitis1

Pharmacoeconomics

Manufacturers
  • Allergan herbert div allergan inc
  • Actavis mid atlantic llc
  • Ivax pharmaceuticals inc
  • Perrigo new york inc
  • Taro pharmaceuticals usa inc
  • Wockhardt eu operations (swiss) ag
  • Chattem inc
Packagers
  • Advanced Pharmaceutical Services Inc.
  • Bioglan Pharmaceuticals Co.
  • Chattem Chemicals Inc.
  • DispenseXpress Inc.
  • Dispensing Solutions
  • Groupe Parima Inc.
  • Ide Interstate
  • Ivax Pharmaceuticals
  • Major Pharmaceuticals
  • Perrigo Co.
  • Pharmaderm
  • Pharmedix
  • Physicians Total Care Inc.
  • Professional Co.
  • Qualitest
  • Quinnova Pharmaceuticals
  • River's Edge Pharmaceuticals
  • Sonar Products Inc.
  • Taro Pharmaceuticals USA
  • Wockhardt Ltd.
Dosage Forms
FormRouteStrength
ShampooTopical1.0000 mL/100mL
ClothTopical
ShampooTopical1 mL/100mL
LiquidTopical10 mg/1mL
Lotion / shampooTopical1 g/100mL
ShampooTopical1 kg/100L
ShampooTopical10 mg/1mL
ShampooTopical325 mL/100mL
ShampooTopical0.6 g/100mL
LiquidTopical1 mL/100mL
ShampooTopical
LotionTopical2.5 mg/100mL
LotionTopical2.5 g/100mL
LotionTopical25 mg/1mL
ShampooTopical22.5 mg/1mL
ShampooTopical23 mg/1mL
Shampoo, suspensionTopical0.0225 mg/1mL
LotionTopical
ShampooTopical1 g/100mL
ShampooTopical1 %
ShampooTopical1.0 %
ShampooTopical0.025 g/1mL
SuspensionTopical
Aerosol, foamTopical1.44 g/70g
SolutionTopical
CreamTopical1 g/56.7g
CreamTopical2.5 %w/w
Prices
Unit descriptionCostUnit
Selenium Sulfide 2.5% Lotion 118ml Bottle19.99USD bottle
Selenium Sulfide 2.5% Lotion 120ml Bottle19.99USD bottle
Selenium sulfide 99% powder5.64USD g
Tersi 2.25% foam2.05USD g
Selenium sulfide 2.25% shampoo0.33USD ml
Selenium sulf 2.5% shampoo0.17USD ml
Selenium 2.5% lotion-shampoo0.1USD ml
Selenium sulfide 2.5% lotion0.1USD ml
Selsun blue shampoo x-medic0.04USD ml
Selsun blue 1% shampoo0.03USD ml
Selsun blue daily shampoo0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)100 °CNot Available
water solubilityPractically insolubleNot Available
Predicted Properties
PropertyValueSource
logP0.91ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity31.98 m3·mol-1ChemAxon
Polarizability9.59 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption+0.9946
Blood Brain Barrier+0.9786
Caco-2 permeable+0.6224
P-glycoprotein substrateNon-substrate0.908
P-glycoprotein inhibitor INon-inhibitor0.9531
P-glycoprotein inhibitor IINon-inhibitor0.9963
Renal organic cation transporterNon-inhibitor0.9254
CYP450 2C9 substrateNon-substrate0.8623
CYP450 2D6 substrateNon-substrate0.8451
CYP450 3A4 substrateNon-substrate0.8077
CYP450 1A2 substrateNon-inhibitor0.7526
CYP450 2C9 inhibitorNon-inhibitor0.7658
CYP450 2D6 inhibitorNon-inhibitor0.9304
CYP450 2C19 inhibitorNon-inhibitor0.8352
CYP450 3A4 inhibitorNon-inhibitor0.891
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7268
Ames testNon AMES toxic0.8363
CarcinogenicityCarcinogens 0.6874
BiodegradationNot ready biodegradable0.9612
Rat acute toxicity2.2807 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.933
hERG inhibition (predictor II)Non-inhibitor0.9694
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on June 13, 2005 13:24 / Updated on April 03, 2021 09:42