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Quinethazone Action Pathway (old)
smpdb.ca/view/SMP0000091Drug actionQuinethazone, also known under the brand-name Hydromox, is a pharmacologically-active small molecule that belongs to a class of drugs called thiazides. Thiazides and thiazide-like drugs are diuretics commonly employed to control hyperten...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Ethacrynic Acid Action Pathway
smpdb.ca/view/SMP0000097Drug actionEtacrynic acid (also known as ethacrynic acid and Edecrin) is a loop diuretic that can inhibit water reabsorption by binding and inhibiting solute carrier family 12 member 1 (also known as sodium-potassium-chloride cotransporter) in the ...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Hydrochlorothiazide Action Pathway
smpdb.ca/view/SMP0000100Drug actionHydroflumethiazide (also known as Esidrix or Oretic) is an organic compound that used for diuretic. It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorpti...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Indapamide Action Pathway
smpdb.ca/view/SMP0000110Drug actionIndapamide (also named as Noranat or Veroxil) is a thiazide-like diuretic drug that can be used to treat hypertension and decompensated heart failure. Indapamide can inhibit sodium-chloride symporter in distal convoluted tubule to preven...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Amiloride Action Pathway
smpdb.ca/view/SMP0000133Drug actionAmiloride is a diuretic that inhibits the sodium channels in the late distal convoluted tubule and collecting tube of the nephron where 1-2% of sodium reabsorption occurs. The inhibition of sodium reabsorption results in increased osmola...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Glucose Transporter Defect (SGLT2)
smpdb.ca/view/SMP0000184DiseaseSGLT2 is a sodium/glucose co-transporter that exists almost exclusively in kidney tissue. It is responsible for approximately 90% of the kidney's reabsorption of glucose, and can be found in the S1 segment of the proximal convoluted tubu...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Hartnup Disorder
smpdb.ca/view/SMP0000189DiseaseHartunup Disorder (HND, Hartnup Disease) is an autosomal recessive disease caused by a mutation in the SLC6A19 which codes for sodium-dependent neutral amino acid transporter B(0). A deficiency in this enzyme results in accumulation of L...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Lysinuric Protein Intolerance
smpdb.ca/view/SMP0000197DiseaseLysinuric protein intolerance (Hyperdibasic aminoaciduria II; Dibasic aminoaciduria II; Hyperdibasic aminoaciduria II; LPI), also called hyperdibasic aminoaciduria type 2 or familial protein intolerance, is an autosomal recessive metabol...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Ziconotide
go.drugbank.com/drugs/DB06283ApprovedInvestigationalZiconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds. … [L13389] To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.[A202835]
Categories: Calcium Channels, N-Type, N-Calcium Channel Receptor AntagonistsTrenonacog alfa
go.drugbank.com/drugs/DB13201InvestigationalHuman coagulation factor IX (EC 3.4.21.22, Christmas factor, plasma thromboplastin component), produced in CHO cells.