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Chlorothiazide Action Pathway
smpdb.ca/view/SMP0000078Drug actionChlorothiazide (also known as Diuril) is an organic compound that used for diuretic. It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption. Solute carr...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Bumetanide Action Pathway
smpdb.ca/view/SMP0000088Drug actionIn the nephron, the think ascending limb reabsorbs 25% of sodium and is a good target for diuretics.
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Cyclothiazide Action Pathway
smpdb.ca/view/SMP0000103Drug actionCyclothiazide (also known as Anhydron or Acquirel) is an organic compound that used for diuretic. It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Metolazone Action Pathway (old)
smpdb.ca/view/SMP0000105Drug actionMetolazone (also known as Zytanix, Zaroxolyn or Mykrox) is an organic compound that used for diuretic. It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsor...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Torsemide Action Pathway
smpdb.ca/view/SMP0000118Drug actionTorsemide, also known as torasemide is a pharmacologically-active small molecule that belongs to the drug class of loop diuretics. It is commonly used to manage hypertension and edema in cases of congestive heart failure as it acts as a ...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Chlorthalidone Action Pathway
smpdb.ca/view/SMP0000122Drug actionChlorthalidone (also known as chlorthalidone or phthalamudine) is an organic compound that used for diuretic. It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water ...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Triamterene Action Pathway
smpdb.ca/view/SMP0000132Drug actionTriamterene is a diuretic that belongs to the potassium-sparing class of drugs which are commonly used to manage hypertension and edema. It acts by blocking epithelial sodium channels in the late distal convoluted tubule of the nephron. ...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Spironolactone Action Pathway
smpdb.ca/view/SMP0000134Drug actionSpironolactone is a potassium-sparing diuretic. It acts by competing with aldosterone for its receptor inside the principal cells of the late distal tubule and collecting tubule. Aldosterone increases sodium reabsorption and potassium ex...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Iminoglycinuria
smpdb.ca/view/SMP0000193DiseaseIminoglycinuria, also called familial iminoglycinuria, is an autosomal recessive disorder of renal reabsorption caused primarily by a defective SLC36A2 gene. SLC36A2 codes for a proton-coupled amino acid transporter which facilitates the...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1Glucose Transporter Defect (SGLT2)
smpdb.ca/view/SMP0000245DiseaseThe major reabsorptive mechanism for D-glucose in the kidney is known to involve a lower affinity, high capacity Na()/glucose cotransporter, which is located in the early proximal convoluted tubule segment S1 and has a Na()-to-glucose co...
Enzymes: Y+L amino acid transporter 2, Y+L amino acid transporter 1