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Displaying results 2731 - 2740 of 10000 in total
  1. Drug

    Fomepizole

    go.drugbank.com/drugs/DB01213
    ApprovedVet approved

    Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.

    Synonyms: 4-methylpyrazol, 4-methylpyrazoleCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Inhibitors
  2. Drug

    Lisaftoclax

    go.drugbank.com/drugs/DB18054
    Investigational

    Lisaftoclax is a novel, orally active, selective and potent BCL-2 inhibitor

    Synonyms: 4-(4-((6-(4-chlorophenyl)spiro(3.5)non-6-en-7-yl)methyl)-piperazin-1-yl)-n-((3-nitro-4-(((2s)-1,4-dioxan-2-ylmethyl)amino)phenyl)sulfonyl)-2-(1hpyrrolo(2,3-b)pyridin-5-yloxy)benzamide, 4-{4-{[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl}-piperazin-1-yl}-N-{{3-nitro-4-[((2S)-1,4-dioxan-2-ylmethyl)amino]phenyl}sulfonyl}-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamideCategories: Heterocyclic Compounds, 1-Ring
  3. Drug

    Testosterone cypionate

    go.drugbank.com/drugs/DB13943
    ApprovedInvestigational

    It was developed by the company Pharmacia and Upjohn and FDA approved on July 25, 1979. … Testosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesProducts: DEPO-TESTOSTERONE STERILE SOLUTION 100 mg/ml, DEPO-TESTOSTERONE STERILE SOLUTION 200 mg/ml
  4. Drug

    Barium sulfate

    go.drugbank.com/drugs/DB11150
    Approved

    It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield [L1957]. This drug is used as a contrast agent in diagnostic x-ray procedures.

    Mixtures: E-Z HD SULFATODE BARIO PARA SUSPENSION, E-Z HD SULFATODE BARIO PARA SUSPENSIONCategories: X-Ray Contrast Activity, X-Ray Contrast Media, Non-Iodinated
  5. Drug

    Bavdegalutamide

    go.drugbank.com/drugs/DB19032
    Investigational

    Bavdegalutamide is under investigation in clinical trial NCT03888612 (Trial of ARV-110 in Patients With Metastatic Castration Resistant Prostate Cancer).

    Synonyms: 3-pyridazinecarboxamide, n-(trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1h-isoindol-5-yl)-1-piperazinyl)methyl)-1-piperidinyl)-, N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1h-isoindol-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide
  6. Drug

    Ranibizumab

    go.drugbank.com/drugs/DB01270
    ApprovedInvestigational

    Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment directed against human vascular endothelial growth factor A (VEGF-A), which is a glycoprotein implicated in the pathophysiology … BYOOVIZ, a biosimilar of LUCENTIS, was approved by Health Canada in March 2022, making it the first and only biosimilar drug of ranibizumab available in Canada.

    Products: LUCENTIS® 10 MG /ML SOLUCION INYECTABLE, LUCENTİS 10 MG/ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN FLAKON, 1 ADET
  7. Drug

    LM-030

    go.drugbank.com/drugs/DB18283
    Investigational

    Synonyms: (S)-2-ISOBUTYRYLAMINO-PENTANEDIOIC ACID 5-AMIDE 1-{[(2S,5S,8S,11R,12S,15S,18S,21R)-2,8-BIS-((S)-SEC-BUTYL)-21-HYDROXY-5-(4-HYDROXY-BENZYL)-15-ISOBUTYL-4,11-DIMETHYL-3,6,9,13,16,22-HEXAOXO-10-OXA-1,4,7,14,17, L-ISOLEUCINE, N2-(2-METHYL-1-OXOPROPYL)-L-GLUTAMINYL-L-THREONYL-L-LEUCYL-(.ALPHA.S,3S,6R)-3-AMINO-6-HYDROXY-.ALPHA.-((1S)-1-METHYLPROPYL)-2-OXO-1-PIPERIDINEACETYL-N-METHYL-L-TYROSYL-, (6->2)-LACTONE
  8. Drug

    Dimethyl fumarate

    go.drugbank.com/drugs/DB08908
    ApprovedInvestigational

    It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated

    Synonyms: (E)-But-2-enedioic acid dimethyl esterProducts: YARDIX® 120 MG, D-FUMARIC 120 CAPSULAS DE LIBERACION RETARDADA 120 MG
  9. Drug

    Pembrolizumab

    go.drugbank.com/drugs/DB09037
    ApprovedInvestigational

    [A18829] It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds. … It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation.

    Categories: PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsProducts: KEYTRUDA® 100 MG, KEYTRUDA 100 MG/4 ML IV INFUZYONLUK COZELTI İÇEREN FLAKON, 1 ADET
  10. Drug

    Phentermine

    go.drugbank.com/drugs/DB00191
    ApprovedIllicitInvestigational

    This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers … Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.

    International brands: Obestin-30Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates