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Pegcetacoplan
go.drugbank.com/drugs/DB16694ApprovedInvestigationalPegcetacoplan is a complement inhibitor indicated in the treatment of paroxysmal nocturnal hemoglobinuria (PNH). … [A235000,A235005] Pegcetacoplan is a pegylated C3 inhibitor that can disrupt the processes leading to both forms of hemolysis that threaten patients with PNH.
Products: EMPAVELI® 54 MG/ML SOLUCIÓN INYECTABLENADH
go.drugbank.com/drugs/DB00157ApprovedNutraceuticalNADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. … It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed)
Mixtures: Folika-V, Nutra-ZCategories: Heterocyclic Compounds, 2-RingHuman C1-esterase inhibitor
go.drugbank.com/drugs/DB06404ApprovedInvestigationalThe primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. … The disease is characterized by acute attacks of painful, and in some cases, fatal swelling of several soft tissues or edema, which may last up to five days when untreated.[L16586, L16606]
Products: CİNRYZE 500 IU/5 ML IV ENJEKSİYONLUK ÇÖZELTİ İÇİN LİYOFİLİZE TOZ VE ÇÖZÜCÜ, 2 ADETTeniposide
go.drugbank.com/drugs/DB00444ApprovedInvestigationalAccumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle. … Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.
Categories: Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 4'-demethylepipodophyllotoxin 9-(4,6-O-(R)-2-thenylidene-beta-D-glucopyranoside)Trioxsalen
go.drugbank.com/drugs/DB04571ApprovedWithdrawnIn research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.[3] The compound is has been explored for development of antisense oligonucleotides that can be … cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: 6-hydroxy-β,2,7-trimethyl-5-benzofuranacrylic acid, δ-lactone, 2',4,8-TrimethylpsoralenRezafungin
go.drugbank.com/drugs/DB16310ApprovedInvestigationalRezafungin has a half-life higher than 130 hours and can be administered once a week instead of daily. … [A258398,L45633] Clinical studies have shown that rezafungin is non-inferior to caspofungin for the treatment of candidaemia and invasive candidiasis.
Categories: Heterocyclic Compounds, 1-RingSynonyms: Echinocandin B, 1-((4R,5R)-4-hydroxy-N2-((4''-(pentyloxy)(1,1':4',1''-terphenyl)-4-yl)carbonyl)-5-(2-(trimethylammonio)ethoxy)-l-ornithine)-4-((4S)-4-hydroxy-4-(4-hydroxyphenyl)-l-allothreonine)-Latamoxef
go.drugbank.com/drugs/DB04570ApprovedLatamoxef is a broad- spectrum beta-lactam antibiotic similar in structure to the cephalosporins except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain cephalosporins … It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
Categories: Heterocyclic Compounds, 2-RingRanolazine
go.drugbank.com/drugs/DB00243ApprovedInvestigational[L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440] … [A189234] Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsProducts: RANEXICOR ® 500, RANEXICOR ® 1000Mannitol
go.drugbank.com/drugs/DB00742ApprovedInvestigationalMannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a … this indication under the name BRONCHITOL® by Chiesi USA Inc.
Synonyms: D-Mannitol, D-(-)-MannitolInternational brands: Mannisol APralatrexate
go.drugbank.com/drugs/DB06813ApprovedInvestigational[A246703] As such, pralatrexate is thought to have a better therapeutic window compared to other antifolate analogs due to the novel target of RFC. … Pralatrexate is an antifolate for the treatment of relapsed or refractory peripheral T-cell lymphoma [L37674].
Categories: Heterocyclic Compounds, 2-RingSynonyms: (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid, (2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid