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Tiagabine
go.drugbank.com/drugs/DB00906ApprovedTiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does app...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesParicalcitol
go.drugbank.com/drugs/DB00910ApprovedInvestigationalParicalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal fail...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesMesoridazine
go.drugbank.com/drugs/DB00933ApprovedWithdrawnA phenothiazine antipsychotic with effects similar to chlorpromazine.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesFelbamate
go.drugbank.com/drugs/DB00949ApprovedIt has a weak inhibitory effect on GABA receptor binding sites.
Categories: NMDA Receptor Antagonists, Cytochrome P-450 SubstratesIsoniazid
go.drugbank.com/drugs/DB00951ApprovedInvestigationalAntibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsNorgestimate
go.drugbank.com/drugs/DB00957ApprovedInvestigationalNorgestimate was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with eth...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesPindolol
go.drugbank.com/drugs/DB00960ApprovedInvestigationalPindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythm...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsZaleplon
go.drugbank.com/drugs/DB00962ApprovedIllicitZaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAripiprazole
go.drugbank.com/drugs/DB01238ApprovedInvestigationalAripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation ...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesClomipramine
go.drugbank.com/drugs/DB01242ApprovedInvestigationalVet approvedα<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention
Categories: Serotonin Receptor Antagonists, P-glycoprotein inhibitors