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Diosmin
go.drugbank.com/drugs/DB08995ApprovedInvestigational[A232885] Diosmin is a bioflavonoid isolated from various plants or synthesized from [hesperidin]. … Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease.
Mixtures: VENAFIX (Diosmin and Hesperidin Tablet)Iptacopan
go.drugbank.com/drugs/DB16200ApprovedInvestigationalThis approval was based on favorable results obtained from the phase III APPL-PNH and APPOINT-PNH studies, where 82.3% and 77.5% of patients experienced a sustained hemoglobin improvement without transfusions … [A262566] Factor B is a positive regulator of the alternative complement pathway, where it activates C3 convertase and subsequently C5 convertase.
Categories: Antineoplastic and Immunomodulating AgentsBucetin
go.drugbank.com/drugs/DB13278ApprovedWithdrawnBucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication.[A175636]
Tezacaftor
go.drugbank.com/drugs/DB11712ApprovedInvestigational[L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to manage cystic fibrosis.[L6814] This drug was approved by the FDA on February 12, 2018. … [L4894] Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, an ion
Categories: ivacaftor and tezacaftor, ivacaftor, tezacaftor and elexacaftorDanaparoid
go.drugbank.com/drugs/DB06754ApprovedWithdrawnThe active constituents are heparan, dermatan and [DB09301] [T28], and they are isolated from the porcine intestinal mucosa [FDA Label]. … It is chemically distinct from heparin by containing different protein binding properties, thus has lower cross-reactivity in heparin-intolerant patients.
Categories: Heparin and similars, Blood and Blood Forming OrgansBone Metastases
go.drugbank.com/conditions/DBCOND0028830Synonyms: Secondary malignant neoplasm of bone and bone marrowTea tree oil
go.drugbank.com/drugs/DB11218ApprovedNutraceuticalTea tree oil is an essential oil derived mainly from the Australian native plant _Melaleuca alternifolia_ via steam distillation of the of the leaves and terminal branches [A32439]. … The dermatological use of tea tree oil has been investigated by various studies, where several studies have suggested the uses of this oil for the treatment of acne vulgaris, seborrheic dermatitis, and
Mixtures: Muscle and Joint Heat Cream, Bee Venom Wart And Tags Removal TreatmentProducts: Jeopureun Chowon Wiae Hand sanitizerTrolamine
go.drugbank.com/drugs/DB13747ApprovedInvestigationalTrolamine contains small amounts of diethanolamine and ethanolamine and may also act as an antioxidant against the auto-oxidation of animal and vegetable fats [A27174]. … It is commonly used as a pH adjuster and surfactant in industrial and cosmetic products such as skin and hair conditioning products.
Mixtures: RUNYI MIAOJIE Hand sanitizer, RUNYI MIAOJIE Hand sanitizerCategories: Preparations for Treatment of Wounds and UlcersUridine triacetate
go.drugbank.com/drugs/DB09144ApprovedBy pre-administering with uridine (as the prodrug uridine triacetate), higher doses of 5-FU can be given allowing for improved efficacy and a reduction in toxic side effects [A18578]. … Additionally, orotic acid from the de novo pyrimidine pathway that cannot be converted to UMP is excreted in the urine, accounting for the common name of the disorder, orotic aciduria.
Categories: Alimentary Tract and Metabolism, Nucleic Acids, Nucleotides, and NucleosidesEmapalumab
go.drugbank.com/drugs/DB14724ApprovedInvestigationalEmapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018. … [A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority review and breakthrough therapy.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating Agents