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Aceclofenac

It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies [A19667, A19668, A19670].

Amylocaine

Although amylocaine could be administered topically or injected, it was most widely used for spinal anesthesia [L1882]. … Despite the introduction of using cocaine injections for regional anesthesia in 1884, non-addictive substitutes were sought after immediately [L1882].

Hyaluronidase (human recombinant)

Hyaluronidase (human recombinant) (INN Vorhyaluronidase alfa) is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing a DNA plasmid encoding for a soluble fragment of human hyaluronidase … [A199026] Hyaluronidase has been used in surgical settings for at least the past 60 years to improve the diffusion of local anesthetics.

Sodium ferric gluconate complex

Sodium ferric gluconate complex is an iron replacement product for treatment of iron deficiency anemia.

Cyclandelate

Cyclandelate is not approved for use in the U.S. or Canada, but is approved in various European countries.

Levamisole

[A178117] It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations[A178123] Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. … [A178117, A178123] Levamisole was withdrawn from the American market in 2000 due to its ability to cause serious adverse effects, including agranulocytosis.

Hexocyclium

It was once available under the tradename Tral marketed by Abbvie Inc. but has been discontinued. … Hexocyclium is a muscarinic acetylcholine receptor antagonist which was presumably used in the treatment of gastric ulcer or diarrhea.

Valerian

Valerian is a food ingredient permitted for direct addition to food for human consumption as a natural flavoring substance. … [DB00313] is a derivative of valeric acid, which is obtained from the plant root.

Calcium phosphate dihydrate

Felodipine

It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. … By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction.