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Etretinate
go.drugbank.com/drugs/DB00926ApprovedWithdrawnEtretinate is a medication used to treat severe psoriasis. It is a synthetic aromatic retinoid.
Categories: Antipsoriatics for Systemic Use, Retinoids for Treatment of PsoriasisDAS-431 IV
go.drugbank.com/drugs/DB05432ExperimentalDAS-431 IV is a dopamine D1 receptor agonist developed by DrugAbuse Sciences for the treatment of Addictions, Schizophrenia, Schizoaffective Disorders, Dementia, Parkinson's Disease, Strokes etc.
Doxepin
go.drugbank.com/drugs/DB01142ApprovedInvestigational[L5971] However, in 2010 it was approved for the treatment of insomnia. The latter indication was presented by Pernix Therapeutics.[L5974] … [T83] In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline
Categories: Antidepressive Agents Indicated for DepressionProducts: DOXEPIN AL 50, DOXEPIN AL 100L-Acetylleucine
go.drugbank.com/drugs/DB16956ApprovedInvestigationalLevacetylleucine (L-acetylleucine) is a modified acetylated derivative of the amino acid [leucine]. The racemic (i.e. DL-) form has been available in France since 1957 for the treatment of vertigo. … [A264439] In September 2024, the FDA approved levacetylleucine for the treatment of select patients with NPC.[L51444]
Synonyms: Acetyl-l-leucine, Acetylleucine, l-AN0128
go.drugbank.com/drugs/DB05054InvestigationalAN0128 is a good candidate for a topical antibiotic and is currently being developed by Anacor as a novel therapeutic for acne and atopic dermatitis. … AN0128 is a novel compound that contains a boron atom within a borinic acid complex.
Piperazine
go.drugbank.com/drugs/DB00592ApprovedVet approvedWithdrawnFirst used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. … Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful.
Products: PIPERAZINA AL 10%, PIPERAZINA AL 20%Ingenol mebutate
go.drugbank.com/drugs/DB05013ApprovedWithdrawnPEP005 is a selective small molecule activator of protein kinase C (PKC) extracted from the plant Euphorbia peplus, whose sap has been used as a traditional medicine for the treatment of skin conditions … Picato gel is indicated for the topical treatment of actinic keratosis. Before approval, ingenol mebutate was called PEP005 as an investigational drug.
Sofpironium
go.drugbank.com/drugs/DB19325Approved[A264153] Sofpironium is rapidly converted to a less active metabolite, BBI-4010, after exerting its activity, thereby limiting the incidence and/or severity of systemic anticholinergic effects. … Sofpironium is a "soft" anticholinergic analog of [glycopyrronium] that has been modified with a readily hydrolyzable ester moiety.
Griseofulvin
go.drugbank.com/drugs/DB00400ApprovedVet approvedAn antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.
Categories: Antifungals for Topical Use, Antifungals for Systemic UseRagweed pollen extract
go.drugbank.com/drugs/DB05368ApprovedWithdrawnThe company has initiated a phase III trial with its product for oral immunotherapy of ragweed allergy. … While traditional disease-modifying immunotherapeutics are administered by subcutaneous injection, Curalogic has developed a more convenient orally administered drug.