DB00926ApprovedWithdrawnSmall molecule
Etretinate is a medication used to treat severe psoriasis. It is a synthetic aromatic retinoid. The mechanism of action of etretinate is still incompletely understood although, like retinoic acid, it... It is thought to bind to the retinoic acid receptors.
- Mechanism
- Curator reviewed
The mechanism of action of the active metabolite, acitretin, is unknown, however it is believed to work by targeting specific receptors (retinoid receptors) in the skin which help normalize the growth cycle of skin cells.
- Primary indication
- For the treatment of severe psoriasis in adults.Curator reviewed
- Formula / weight
- C23H30O3 · 354.4825 g/mol (avg)
- Code names
- RO 10-9359
Resolves to
Clinical / RWD
Structure
InChIKey
HQMNCQVAMBCHCO-DJRRULDNSA-NSMILESCCOC(=O)C=C(C)C=CC=C(C)C=CC1=C(C)C(C)=C(OC)C=C1CWhat you can answer from here — as of September 12, 2026
6Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Etretinate, and which of those have an active Phase 3 trial?
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