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Bretylium
go.drugbank.com/drugs/DB01158ApprovedBretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular … Recent evidence has shown that bretylium may also inhibit the Na,K-ATPase by binding to the extracellular K-site.
Mixtures: Bretylium Tosylate 0.4% and Dextrose 5% Inj, Bretylium Tosylate 0.2% and Dextrose 5% InjProducts: Bretylate Inj 50mg/ml, Bretylium Tosylate Inj 50mg/mlNitrous acid
go.drugbank.com/drugs/DB09112ApprovedInvestigationalNitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. … There is also research to investigate its applicability towards treatments for heart attacks, brain aneurysms, pulmonary hypertension in infants, and Pseudomonas aeruginosa infections.
Mixtures: Rite Aid Enamel GuardCategories: Indicators and Reagents, Diet, Food, and NutritionStabilin-1
go.drugbank.com/bio_entities/BE0010944TargetHumansBinds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. … Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system
Synonyms: Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1Ticagrelor
go.drugbank.com/drugs/DB08816ApprovedInvestigational[A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU,[L14207]. Ticagrelor was granted EMA approval on 3 December 2010. … [A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism.[A2903] Unlike [clopidogrel], ticagrelor is not a prodrug.
Categories: Blood and Blood Forming Organs, Nucleic Acids, Nucleotides, and NucleosidesProducts: Trixevas 90mg FC Tablet, BRILINTA 90MG FILM-COATED TABLETMeningococcal polysaccharide vaccine group W-135
go.drugbank.com/drugs/DB13887ApprovedInvestigationalMeningococcal group W-135 polysaccharide is group-specific polysaccharide antigens extracted and purified from *Neisseria meningitidis* serogroup W-135. … It is subcutaneously administered as an active immunization against the invasive meningococcal disease caused by the serogroup W-135.
Mixtures: Menveo Powder and Solution for Solution for Injection, NIMENRIX POWDER AND SOLVENT FOR SOLUTION FOR INJECTIONLevamlodipine
go.drugbank.com/drugs/DB09237ApprovedInvestigational[L10833] As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity. … [L10833] This medication was first marketed in Russia and India before being granted FDA approval.
Mixtures: ALENCAL VALS 2.5/160MG TABLETAS RECUBIERTAS, ALENCAL VALS 2.5/160MG TABLETAS RECUBIERTASVoclosporin
go.drugbank.com/drugs/DB11693ApprovedInvestigationalWithin 10 years of being diagnosed with SLE, 5-20% of those suffering from LN develop end-stage kidney disease, a fatal condition. … to older calcineurin inhibitors.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsMilnacipran
go.drugbank.com/drugs/DB04896ApprovedInvestigationalMilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment … Furthermore, in 2009 the US FDA approved milnacipran for the additional indication of treating fibromyalgia [F3925], although other regional regulatory authorities like the EMA, among others, have not
Categories: Milnacipran and enantiomer, Serotonin and Noradrenaline Reuptake InhibitorsBenign Prostatic Hyperplasia (BPH)
go.drugbank.com/conditions/DBCOND0033444Synonyms: Glandular, stromal and muscular hyperplasia of prostate gland, Glandular, stromal AND/OR muscular hyperplasia of prostate glandTiopronin
go.drugbank.com/drugs/DB06823ApprovedIt is similar to d-penicillamine in use and efficacy, but offers the advantage of far less adverse effects. … Tiopronin is used as a second-line therapy to control the rate of cystine precipitation and excretion, and prevent kidney stone formation.
Categories: Reducing and Complexing Thiol, Amino Acids, Peptides, and Proteins