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Ingenol disoxate
go.drugbank.com/drugs/DB15109InvestigationalIngenol disoxate is under investigation in clinical trial NCT02120456 (Safety and Efficacy of Escalating Doses of LEO 43204 Applied Once Daily for Two Consecutive Days on Approximately 250 cm2 on Trunk
Chamaemelum nobile flower
go.drugbank.com/drugs/DB14328InvestigationalChamaemelum nobile flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Synonyms: Chamaemelum Nobile (L.) All. (Anthemis Nobilis L.)Mixtures: DENTINOX 3.4 MG/G + 3.2 MG/G + 150 MG/G JEL, 20 G, DENTINOX 3.4 MG/G + 3.2 MG/G + 150 MG/G JEL, 10 GDicoumarol
go.drugbank.com/drugs/DB00266ApprovedDicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K.
Synonyms: bis(4-hydroxycoumarin-3-yl)methane, 3,3'-methylenebis(4-hydroxy-2H-1-benzopyran-2-one)Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesLevomefolic acid
go.drugbank.com/drugs/DB11256ApprovedIt is available commercially as a crystalline form of the calcium salt (Metafolin(R)), which has the stability required for use as a supplement [A19276]. … Levomefolate is approved as a food additive and is designated a GRAS (generally regarded as safe) compound [L773].
Synonyms: L-5-MTHF, N-[4-[[[(6S)-2-Amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-L-glutamic acidMixtures: PNV Tabs 20-1, Obstetrix ECIC41
go.drugbank.com/drugs/DB05776InvestigationalIC41 is a therapeutic peptide vaccine. It is being devloped by Intercell AG for the treatment of hepatitis C. … The vaccine consists of five synthetic peptides (IPEP83, 84, 87, 89,1426) harboring HCV CD4 and CD8 T-cell epitopes and the synthetic adjuvant poly-L-arginine.
Phosphoaminophosphonic acid guanylate ester
go.drugbank.com/drugs/DB02082ExperimentalA non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. … The nucleotide is a potent stimulator of adenylate cyclase.
Synonyms: Gpp(NH)p, 5'-guanylylimidodiphosphateCategories: Heterocyclic Compounds, 2-Ringalpha-Linolenic acid
go.drugbank.com/drugs/DB00132ApprovedInvestigationalNutraceuticalWithdrawnAlpha-linolenic acid (ALA) is a polyunsaturated omega-3 fatty acid. It is a component of many common vegetable oils and is important to human nutrition.
Synonyms: (Z,Z,Z)-9,12,15-octadecatrienoic acid, α-linolenic acidMixtures: SIMILAC ALIMENTUM 400 G TOZ, PRIM E CAPSULEThymol
go.drugbank.com/drugs/DB02513ApprovedInvestigationalIt has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed) … A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations.
Synonyms: 5-Methyl-2-(1-Methylethyl)Phenol, 2-isopropyl-5-methylphenolMixtures: VICKS VAPORUB BUHARLASAN MERHEM, 1 ADETOleic Acid
go.drugbank.com/drugs/DB04224ApprovedInvestigationalVet approvedIt is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)
Mixtures: Huile D'onagre Vitamin ETelisotuzumab vedotin
go.drugbank.com/drugs/DB15104ApprovedInvestigational[L53158] The c-Met protein is found to be overexpressed in approximately 25% of advanced EGFR wild type, non-squamous NSCLC patients and is associated with poor prognosis and limited treatment options. … Telisotuzumab vedotin is an antibody-drug conjugate comprising [telisotuzumab], a c-Met-directed humanized IgG1κ monoclonal antibody, conjugated to monomethyl auristatin E (MMAE), a small molecule microtubule-disrupting
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors