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Displaying results 2871 - 2880 of 8694 in total
  1. Drug

    Ancestim

    go.drugbank.com/drugs/DB09103
    ApprovedWithdrawn

    It is a 166 amino acid protein produced by E. coli with an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal … It was submitted to the FDA under the status of recommendation for approval with a 10 to 1 votes.

  2. Drug

    Prednisone

    go.drugbank.com/drugs/DB00635
    ApprovedInvestigationalVet approved

    A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. Prednisone was granted FDA approval on 21 February 1955.

    Categories: Corticosteroids for Systemic Use, Corticosteroids for Systemic Use, PlainProducts: Prednisone D/P, P- Pack Prednisone 20mg, 7- Day Tapering Dose Pack
  3. Drug

    Bromodiphenhydramine

    go.drugbank.com/drugs/DB01237
    Approved

    Bromodiphenhydramine is an ethanolamine antihistamine with antimicrobial property. Bromodiphenhydramine is used in the control of cutaneous allergies.

    Synonyms: β-(p-bromobenzhydryloxy)ethyldimethylamine, β-dimethylaminoethyl p-bromobenzhydryl etherCategories: Antihistamines for Systemic Use
  4. Drug

    Rasagiline

    go.drugbank.com/drugs/DB01367
    ApprovedInvestigational

    Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
  5. Target

    Gamma-aminobutyric acid type B receptor subunit 1

    go.drugbank.com/bio_entities/BE0000217
    TargetHumans

    Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating … Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688).

    Polypeptides: Gamma-aminobutyric acid type B receptor subunit 1Synonyms: GABA-B receptor 1
  6. Target

    Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

    go.drugbank.com/bio_entities/BE0000628
    TargetHumans

    Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells

    Polypeptides: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
  7. Target

    Scavenger receptor cysteine-rich type 1 protein M130

    go.drugbank.com/bio_entities/BE0003375
    TargetHumans

    Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. … May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme.

    Polypeptides: Scavenger receptor cysteine-rich type 1 protein M130Synonyms: Hemoglobin scavenger receptor
  8. Target

    Putative high affinity immunoglobulin gamma Fc receptor IB

    go.drugbank.com/bio_entities/BE0004684
    TargetHumans

    May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response

    Polypeptides: Putative high affinity immunoglobulin gamma Fc receptor IBSynonyms: IgG Fc receptor IB, Fc gamma receptor IB pseudogene
  9. Target

    Nuclear receptor subfamily 4 group A member 3

    go.drugbank.com/bio_entities/BE0008998
    TargetHumans

    Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. … In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity).

    Polypeptides: Nuclear receptor subfamily 4 group A member 3Synonyms: Nuclear hormone receptor NOR-1, Neuron-derived orphan receptor 1
  10. Target

    Nuclear receptor subfamily 1 group D member 2

    go.drugbank.com/bio_entities/BE0009348
    TargetHumans

    May play a role in the circadian control of neutrophilic inflammation in the lung (By similarity) … Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression.

    Polypeptides: Nuclear receptor subfamily 1 group D member 2Synonyms: Rev-erb alpha-related receptor, Orphan nuclear hormone receptor BD73