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Displaying results 281 - 290 of 10000 in total
  1. Drug

    Minocycline

    go.drugbank.com/drugs/DB01017
    ApprovedInvestigational

    [A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines. … Minocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.

    Synonyms: 7-Dimethylamino-6-demethyl-6-deoxytetracycline, (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamideProducts: Minocin Cap 50mg, Minocin Cap 100mg
  2. Drug

    Capsaicin

    go.drugbank.com/drugs/DB06774
    ApprovedInvestigational

    The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia. … Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements

    Mixtures: Dfs 1.5%/ms 25%/menth 6%/cap 0.025% Pak, DFS 75mg DR/MS 25%/MENTH 6%/CAP 0.025% PAKCategories: Cytochrome P-450 Substrates, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates
  3. Drug

    Polymyxin B

    go.drugbank.com/drugs/DB00781
    ApprovedInvestigationalVet approved

    Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. … Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line[A176429].

    Synonyms: Polymyxin B, Polimixina BInternational brands: Polomyxin B
  4. Drug

    Pramocaine

    go.drugbank.com/drugs/DB09345
    Approved

    Pramocaine is available by itself and in combination with other medications in various topical preparations. … It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation.

    Mixtures: Up and Up Hemorrhoidal, Up and Up multi action antibioticCategories: Heterocyclic Compounds, 1-Ring
  5. Drug

    Pentoxifylline

    go.drugbank.com/drugs/DB00806
    ApprovedInvestigational

    [A226608] Pentoxifylline has been marketed in Europe since 1972; PTX extended-release tablets sold under the trade name TRENTAL by US Pharm Holdings were first approved by the FDA on Aug 30, 1984, but … A branded product, PENTOXIL, marketed by Upsher-Smith Laboratories, and generic forms marketed by Valeant Pharmaceuticals and APOTEX have been available since the late 1990s.[L30300]

    Mixtures: Betamethasone Dipropionate 0.05% / Minoxidil 5% / Niacinamide 2% / Pentoxifylline 0.5%Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 Substrates
  6. Drug

    Fexofenadine

    go.drugbank.com/drugs/DB00950
    ApprovedInvestigational

    [L4269] It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier[L10779] - this is in contrast to previous first-generation … Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms.

    Synonyms: 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acidMixtures: ALERMED® D, FEXU D® SUSPENSION
  7. Target

    Collagen alpha-1(I) chain

    go.drugbank.com/bio_entities/BE0000025
    TargetHumans

    Type I collagen is a member of group I collagen (fibrillar forming collagen)

    Polypeptides: Collagen alpha-1(I) chainSynonyms: Alpha-1 type I collagen
  8. Target

    Collagen alpha-2(I) chain

    go.drugbank.com/bio_entities/BE0002141
    TargetHumans

    Type I collagen is a member of group I collagen (fibrillar forming collagen)

    Polypeptides: Collagen alpha-2(I) chainSynonyms: Alpha-2 type I collagen
  9. Target

    Casein kinase I isoform epsilon

    go.drugbank.com/bio_entities/BE0003512
    TargetHumans

    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:1255651...

    Polypeptides: Casein kinase I isoform epsilon
  10. Target

    Keratin, type I cytoskeletal 14

    go.drugbank.com/bio_entities/BE0009085
    TargetHumans

    Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms heteropolymers with type II keratin KRT5, contributing to the keratin intermediate filament network that confers mechanical strength and...

    Polypeptides: Keratin, type I cytoskeletal 14