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Padimate A
go.drugbank.com/drugs/DB11229ApprovedWithdrawnIn Europe this chemical was withdrawn in 1989 for unstated reasons and in the US it was never approved for use in sunscreens. … Padimate A is an ester derivative of PABA and an ingredient in some sunscreens.
Human Rho(D) immune globulin
go.drugbank.com/drugs/DB11597ApprovedImmune globullin was purified via ion-exchange chromatography method and prepared from pools of human plasma, where the donors are Rho (D)-negative donors who have been immunized with Rho(D)-positive RBCs … It was approved by FDA as treatment for suppression of rhesus (Rh) isoimmunization or chronic immune thrombocytopenic purpura (ITP) in adults.
Categories: Amino Acids, Peptides, and Proteins, Immune Sera and ImmunoglobulinsMenadione
go.drugbank.com/drugs/DB00170ApprovedNutraceuticalA synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Synonyms: Vitamin K 3Mixtures: LIBAVIT-K 20 MG AMPUL, 5 ADETFutibatinib
go.drugbank.com/drugs/DB15149ApprovedInvestigationalFutibatinib is an inhibitor of Fibroblast Growth Factor receptor (FGFR), which comprises a group of receptor tyrosine kinases that play a key role in cell proliferation, differentiation, migration, and … FGFR was investigated in oncology as a therapeutic target, as FGFR genomic aberrations and dysregulated FGFR signalling pathways are observed in some cancers such as cholangiocarcinoma and urothelial malignancies
Categories: Antineoplastic and Immunomodulating AgentsExcitatory amino acid transporter 3
go.drugbank.com/bio_entities/BE0001054TargetTransporterHumansPlays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). … Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949).
Synonyms: Neuronal and epithelial glutamate transporterRibosomal protein S6 kinase alpha-4
go.drugbank.com/bio_entities/BE0004614TargetHumans/FOS and c-jun/JUN. … Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and
Synonyms: Nuclear mitogen- and stress-activated protein kinase 2Zinc transporter ZIP12
go.drugbank.com/bio_entities/BE0009897TransporterHumansMay play a role in neurulation and neurite extension. … Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane. The transport activity is temperature dependent.
Synonyms: Zrt- and Irt-like protein 12Zinc transporter ZIP13
go.drugbank.com/bio_entities/BE0009900TransporterHumansFunctions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:21917916, PubMed:23213233).
Synonyms: Zrt- and Irt-like protein 13Gilteritinib
go.drugbank.com/drugs/DB12141ApprovedInvestigational[A40044] Gilteritinib was developed by Astellas Pharma and FDA approved on November 28, 2018. … Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group.
Categories: Antineoplastic and Immunomodulating AgentsProducts: XOSPATA® FILM-COATED TABLETS 40MG, Xospata 40mg Film Coated TabletsBismuth subgallate
go.drugbank.com/drugs/DB13909ApprovedPossessing protective effects on the gastric mucosa, strong astringent effects, and not as yet elucidated antimicrobial and hemostatic actions, bismuth subgallate is most commonly available as an over-the-counter … It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed.
Categories: Antacids and Adsorbents