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Futibatinib
go.drugbank.com/drugs/DB15149ApprovedInvestigationalFutibatinib is an inhibitor of Fibroblast Growth Factor receptor (FGFR), which comprises a group of receptor tyrosine kinases that play a key role in cell proliferation, differentiation, migration, and … FGFR was investigated in oncology as a therapeutic target, as FGFR genomic aberrations and dysregulated FGFR signalling pathways are observed in some cancers such as cholangiocarcinoma and urothelial malignancies
Categories: Antineoplastic and Immunomodulating AgentsDigoxin
go.drugbank.com/drugs/DB00390ApprovedInvestigational[L9143] This drug originates from the foxglove plant, also known as the _Digitalis_ plant[T610], studied by William Withering, an English physician and botanist in the 1780s. … [A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954.
Categories: Digoxin and derivativesExcitatory amino acid transporter 3
go.drugbank.com/bio_entities/BE0001054TargetTransporterHumansPlays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). … Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949).
Synonyms: Neuronal and epithelial glutamate transporterRibosomal protein S6 kinase alpha-4
go.drugbank.com/bio_entities/BE0004614TargetHumans/FOS and c-jun/JUN. … Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and
Synonyms: Nuclear mitogen- and stress-activated protein kinase 2Zinc transporter ZIP12
go.drugbank.com/bio_entities/BE0009897TransporterHumansMay play a role in neurulation and neurite extension. … Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane. The transport activity is temperature dependent.
Synonyms: Zrt- and Irt-like protein 12Zinc transporter ZIP13
go.drugbank.com/bio_entities/BE0009900TransporterHumansFunctions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:21917916, PubMed:23213233).
Synonyms: Zrt- and Irt-like protein 13Bismuth subgallate
go.drugbank.com/drugs/DB13909ApprovedPossessing protective effects on the gastric mucosa, strong astringent effects, and not as yet elucidated antimicrobial and hemostatic actions, bismuth subgallate is most commonly available as an over-the-counter … It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed.
Categories: Antacids and AdsorbentsMolybdenum
go.drugbank.com/drugs/DB11137ApprovedInvestigationalIt is an essential trace dietary element and acts as a critical cofactor in several molybdenum-dependent enzymes that are involved in important cellular reactions and pathways, including xanthine oxidoreductase … Molybdenum is commonly used in metallurgy and other chemical applications however it has essential biological roles in organisms and microorganisms.
Mixtures: Iron 25mg With Vit B-cmplx, Vit C, Cu & Mo, Revit Multi-vitamins and MineralsCategories: Diet, Food, and NutritionBotulinum toxin type B
go.drugbank.com/drugs/DB00042ApprovedThe neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation and chromatography steps. … Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex.
Categories: Enzymes and Coenzymes, Amino Acids, Peptides, and ProteinsBenzoic acid
go.drugbank.com/drugs/DB03793ApprovedInvestigationalTotal Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo. … This leads to excretion of these amino acids and a decrease in ammonia levels. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia.
Mixtures: Sodium Phenylacetate and Sodium Benzoate, Sodium Phenylacetate and Sodium BenzoateCategories: Diet, Food, and Nutrition, Alimentary Tract and Metabolism