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Posizolid
go.drugbank.com/drugs/DB04850InvestigationalIn July 2002, after completion of phase I trials in December 2001, AstraZeneca announced that they were no longer pursuing the development of Posizolid, presumably due to negative trial results (though … Posizolid (AZD2563) is an oxazolidinone antibiotic.
Limaprost
go.drugbank.com/drugs/DB09211InvestigationalOno and DSP also discontinued the development of limaprost alfadex for the additional indication of cervical spondylosis in 2008 due to the failure to demonstrate the anticipated efficacy in a Phase II … Limaprost (as Limaprost alfadex; CAS number 88852-12-4) is an oral prostaglandin E1 analog.
Categories: Prostaglandins EVaborbactam
go.drugbank.com/drugs/DB12107ApprovedInvestigational[A32053] It has been used in trials investigating the treatment of bacterial infections in subjects with varying degrees of renal insufficiency. … Vaborbactam is a β-lactamase inhibitor based on a cyclic boronic acid pharmacophore.
Glatiramer
go.drugbank.com/drugs/DB05259ApprovedInvestigational[A248880] It was approved by the FDA in 1996, and a generic version became available in 2017. … Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine, and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively.
Products: Copaxone 20 mg/ml Injektionslösung in einer Fertigspritze, Copaxone 40 mg/ml Injektionslösung in einer FertigspritzePicolinic acid
go.drugbank.com/drugs/DB05483ExperimentalPicolinic acid has been shown to be an anti-viral in vitro and in vivo, and sometimes works in conjunction with other cytokines such as interferon gamma to affect immune responses. … It acts as an anti-infective and immunomodulator and is produced in approximately 25-50 mg quantities by the body on a daily basis through the breakdown of tryptophan.
Categories: Compounds used in a research, industrial, or household settingDroxidopa
go.drugbank.com/drugs/DB06262ApprovedInvestigationalThe racaemic form (dl-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. … Droxidopa is a precursor of noradrenaline that is used in the treatment of Parkinsonism. It is approved for use in Japan and is currently in trials in the U.S.
Mogamulizumab
go.drugbank.com/drugs/DB12498ApprovedInvestigational[L4168] It was approved for the same indications in Canada in June 2022. … [L4170] On August 8 2018, the U.S.
DL-Methylephedrine
go.drugbank.com/drugs/DB11278ApprovedThe abuse of methylephedrine-containing medications has been reported in Japan. Methylephedrine is not legally available in the United States, but has been identified in cases of drug abuse [L2836]. … Methylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications throughout the world [L2838], [L2839], [L2840].
Salts: DL-Methylephedrine hydrochlorideSynonyms: N-methylephedrine DL-form, (+/-)-N-methylephedrineBucrylate
go.drugbank.com/drugs/DB19727ExperimentalBucrylate has a monoisotopic molecular weight of 153.08 Da.
Categories: Compounds used in a research, industrial, or household settingSulconazole
go.drugbank.com/drugs/DB06820ApprovedSulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for tinea cruris and tinea corporis … [L44592,L44597] Sulconazole appears to be effective and well-tolerated in the treatment of superficial fungal infections.[A255612]