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Dimethyl fumarate
go.drugbank.com/drugs/DB08908ApprovedInvestigationalIt is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated … [L43752] Dimethyl fumarate is marketed under the brand name Tecfidera, and it was the third oral disease-modifying agent for multiple sclerosis approved by the FDA, following [fingolimod] and [teriflunomide
Synonyms: (E)-But-2-enedioic acid dimethyl esterProducts: YARDIX® 240MG, TECFIDERA® 240MGDaclatasvir
go.drugbank.com/drugs/DB09102ApprovedInvestigationalWithdrawnHepatitis C is an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … It exerts its antiviral action by preventing RNA replication and virion assembly via binding to NS5A, a nonstructural phosphoprotein encoded by HCV.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: I-HEP CLASTAVIR 30, I-HEP CLASTAVIR 60Captopril
go.drugbank.com/drugs/DB01197ApprovedInvestigationalCaptopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). … ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Mixtures: CO-ALTIVER, CAPTOPRIL E IDROCLOROTIAZIDE HEXALCategories: P-glycoprotein inhibitors, Agents Acting on the Renin-Angiotensin SystemFormoterol
go.drugbank.com/drugs/DB00983ApprovedInvestigational[L10986] It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. … Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001.
Mixtures: FORMODUAL N. 200/6UG, FORMODUAL N. 200/6UGCategories: Agents to Treat Airway Disease, Cytochrome P-450 SubstratesPhenytoin
go.drugbank.com/drugs/DB00252ApprovedInvestigationalVet approved[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications … [A188826,A188832] Clinicians are advised to initiate therapeutic drug monitoring in patients who require phenytoin since even small deviations from the recommended therapeutic range can lead to suboptimal
Mixtures: Dilantin W Phenobarbital 30mg Cap, Dilantin W Phenobarbital 15mgCategories: Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexHigh affinity immunoglobulin gamma Fc receptor I
go.drugbank.com/bio_entities/BE0000710TargetCarrierHumansHigh affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-i...
Polypeptides: High affinity immunoglobulin gamma Fc receptor ISynonyms: IgG Fc receptor IAntiviral innate immune response receptor RIG-I
go.drugbank.com/bio_entities/BE0012418TargetHumansOverhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). … Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624
Polypeptides: Antiviral innate immune response receptor RIG-ISynonyms: RIG-I, RNA sensor RIG-IDNA-directed RNA polymerase I subunit RPA49
go.drugbank.com/bio_entities/BE0019377TargetHumansComponent of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates (PubMed:24207024, PubMed:34671025 … Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:24207024)
Polypeptides: DNA-directed RNA polymerase I subunit RPA49Synonyms: RNA polymerase I subunit A49, DNA-directed RNA polymerase I subunit EDNA-directed RNA polymerase I subunit RPA2
go.drugbank.com/bio_entities/BE0019741TargetHumansCatalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. … Forms Pol I active center together with the largest subunit POLR1A/RPA1.
Polypeptides: DNA-directed RNA polymerase I subunit RPA2Synonyms: RNA polymerase I subunit 2, DNA-directed RNA polymerase I 135 kDa polypeptideNo gastrointestinal absorption problems
go.drugbank.com/conditions/DBCOND0134182Drugs: PregabalinSynonyms: No gastrointestinal absorption problems