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Pentoxifylline
go.drugbank.com/drugs/DB00806ApprovedInvestigationalPentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties. Although originally developed to treat intermittent claud...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesIndapamide
go.drugbank.com/drugs/DB00808ApprovedInvestigationalThe most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAcetazolamide
go.drugbank.com/drugs/DB00819ApprovedInvestigationalVet approvedOne of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizur...
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsTolazamide
go.drugbank.com/drugs/DB00839ApprovedA sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Synonyms: 1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea, N-(p-Toluenesulfonyl)-N'-hexamethyleniminoureaCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesPerphenazine
go.drugbank.com/drugs/DB00850ApprovedInvestigationalAn antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.
Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 SubstratesChlorphenesin
go.drugbank.com/drugs/DB00856ApprovedSynonyms: glycerol α-p-chlorophenyl ether, 3-(p-chlorophenoxy)-1,2-propanediolCategories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersTerbinafine
go.drugbank.com/drugs/DB00857ApprovedInvestigationalVet approvedTerbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by i...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersRanitidine
go.drugbank.com/drugs/DB00863ApprovedWithdrawnRanitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine].
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsBenzphetamine
go.drugbank.com/drugs/DB00865ApprovedIllicitA sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: RecedeSuprofen
go.drugbank.com/drugs/DB00870ApprovedWithdrawnAn ibuprofen-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. It is no longer approved for use in the United States.
Synonyms: p-2-thenoylhydratropic acid, (±)-2-(p-(2-thenoyl)phenyl)propionic acidCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Inhibitors