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Valdecoxib
go.drugbank.com/drugs/DB00580ApprovedWithdrawnValdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Categories: Genito Urinary System and Sex Hormones, Antiinflammatory and Antirheumatic ProductsPegfilgrastim
go.drugbank.com/drugs/DB00019ApprovedInvestigational[A187607] First developed by Amgen, pegfilgrastim was initially approved by the FDA in 2002 and marketed as Neulasta. It is typically administered via a subcutaneous injection. … activity to filgrastim and binds to the G-CSF receptor to stimulate the proliferation, differentiation, and activation of neutrophils.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsLubiprostone
go.drugbank.com/drugs/DB01046ApprovedInvestigationalActivation of these channels promotes the secretion of a chloride-rich fluid that soften the stool, increase gastrointestinal motility, and induce spontaneous bowel movements (SBM).
Categories: Alimentary Tract and MetabolismCocaine
go.drugbank.com/drugs/DB00907ApprovedIllicitInvestigationalAn alkaloid ester extracted from the leaves of plants including coca. … It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat.
Categories: Analgesics and AnestheticsProducts: Cocaine Hydrochloride Top Sol 40mg/mlPrimaquine
go.drugbank.com/drugs/DB01087ApprovedInvestigationalAdverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404) … An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide.
Categories: Antiparasitic Products, Insecticides and RepellentsBimekizumab
go.drugbank.com/drugs/DB12917ApprovedInvestigational[L39665,L39680] It is the first IL-17 inhibitor to target both IL-17A and IL-17F. … [A244455] It has demonstrated superior efficacy as compared to another IL-17 inhibitor, [secukinumab], as well as [ustekinumab] (an IL-12/23 inhibitor) and [adalimumab] (a TNF inhibitor) in the treatment
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsSertaconazole
go.drugbank.com/drugs/DB01153ApprovedSertaconazole nitrate is an antifungal medication of the imidazole class. It is available in topical formulations for the treatment of skin infections such as athlete's foot.
Categories: Imidazole and Triazole Derivatives, Genito Urinary System and Sex HormonesGlatiramer
go.drugbank.com/drugs/DB05259ApprovedInvestigational[A248880] It was approved by the FDA in 1996, and a generic version became available in 2017. … Glatiramer acetate exhibits several immunomodulatory effects and reduces the relapse rate of relapsing-remitting multiple sclerosis (RRMS) by 30%.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsPruritus Ani
go.drugbank.com/conditions/DBCOND0005710Drugs: Aloe vera leaf · Aluminum subacetate · Benzalkonium · Bismuth subgallate · Bufexamac · Carvasept +8 moreSynonyms: Pruritus Ani, Pruritus ani (finding)Marstacimab
go.drugbank.com/drugs/DB17725ApprovedInvestigational[A264608] Marstacimab is used to prevent bleeding episodes in patients with hemophilia,[L51803] which is an X‐linked bleeding disorder characterized by coagulation clotting factor deficiency. … [L51803] It is a tissue factor pathway inhibitor (TFPI) antagonist, which is an endogenous anticoagulant.
Categories: Blood and Blood Forming Organs, Amino Acids, Peptides, and Proteins