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Sirolimus
go.drugbank.com/drugs/DB00877ApprovedInvestigationalSirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria Streptomyces hygroscopicus, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and iden...
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: P-HYSPLAN, RENACEPTGranisetron
go.drugbank.com/drugs/DB00889ApprovedInvestigationalA serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCocaine
go.drugbank.com/drugs/DB00907ApprovedIllicitInvestigationalAn alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nerv...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesPhenformin
go.drugbank.com/drugs/DB00914ApprovedWithdrawnA biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some c...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesMetronidazole
go.drugbank.com/drugs/DB00916ApprovedInvestigationalMetronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic inf...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesAlmotriptan
go.drugbank.com/drugs/DB00918ApprovedAlmotriptan is in a class of medications called selective serotonin receptor agonists.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesTipranavir
go.drugbank.com/drugs/DB00932ApprovedInvestigationalTipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets the HIV protease. Tipranavir and ritonavir are coadministered to treat HIV.
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsMaprotiline
go.drugbank.com/drugs/DB00934ApprovedMaprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesPhenprocoumon
go.drugbank.com/drugs/DB00946ApprovedInvestigationalWithdrawnCoumarin derivative that acts as a long-acting oral anticoagulant.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesFulvestrant
go.drugbank.com/drugs/DB00947ApprovedInvestigationalIt is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. … Fulvestrant is a drug treatment of hormone receptor (HR)-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates