Search
Hydrocodone
go.drugbank.com/drugs/DB00956ApprovedIllicitInvestigationalThe FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.[L9025] … Hydrocodone's more potent metabolite, [hydromorphone] has also found wide use as an analgesic and is frequently used in cases of severe pain.
Mixtures: P-TussCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesDifamilast
go.drugbank.com/drugs/DB14987ApprovedInvestigational[L56052, A275420] This skin disease occurs most frequently in children and can have an onset as early as within the first 2 years of life. … The drug is indicated for the topical treatment of mild to moderate atopic dermatitis in adults and pediatric patients 2 years of age and older [L55042]. It is approved in Japan and the United States.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InducersNirogacestat
go.drugbank.com/drugs/DB12005ApprovedInvestigationalNirogacestat is a small-molecule gamma-secretase inhibitor that was investigated as a potential treatment for desmoid tumors. … [A262556] Interaction between the notch receptors and their ligands activates proteolytic cleavage by gamma-secretase; therefore, the inhibition of gamma-secretase can potentially inhibit Notch signaling
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesLanadelumab
go.drugbank.com/drugs/DB14597ApprovedInvestigationalLanadelumab, also known as DX-2930, is a human IgG1 monoclonal antibody designed for subcutaneous self-injection. … [L4537] It has been granted priority review, breakthrough therapy, and orphan drug designations for rare diseases based on the results of clinical trials.
ALT-P1
go.drugbank.com/drugs/DB18485InvestigationalALT-P1 is a long-acting recombinant human growth hormone fused to an alpha1-antitrypsin variant. It is under investigation for the treatment of growth hormone deficiency.
PF-04447943
go.drugbank.com/drugs/DB11953InvestigationalPF-04447943 has been investigated for the treatment of Alzheimer's Disease.
PF-00446687
go.drugbank.com/drugs/DB12517InvestigationalPF-00446687 has been investigated for the treatment of Erectile Dysfunction.
Categories: Receptor, Melanocortin, Type 4, agonistsVoacamine
go.drugbank.com/drugs/DB04877ExperimentalVoacamine is an alkaloid isolated from the bark of the _Pescheria fuchsiae folia_ tree. It is an antimalarial drug approved for use in several African countries. … Voacamine is also under investigation for use in modulating multidrug-resistance in tumor cells.
Categories: P-glycoprotein inhibitorsThrombin alfa
go.drugbank.com/drugs/DB11572ApprovedThrombin Alfa is a human coagulation protein produced via recombinant DNA technology from a genetically modified CHO cell line. Thrombin Alfa is identical in amino acid sequence and structurally similar to naturally occurring human throm...