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Symmetric dimethylarginine
go.drugbank.com/drugs/DB02302ExperimentalSynonyms: Guanidino-N(1),N(2)-dimethylarginine, (S)-2-amino-5-(N',N''-dimethylguanidino)pentanoic acidSorafenib
go.drugbank.com/drugs/DB00398ApprovedInvestigationalSorafenib is a bi-aryl urea and an oral multikinase inhibitor. … It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea, 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamideMilnacipran
go.drugbank.com/drugs/DB04896ApprovedInvestigational(BACE-1), which has investigationally been associated with β-amyloid plaque formation - making the agent a possible course of treatment for Alzheimer's disease [A175957]. … Moreover, recent research has shown that the levorotatory enantiomer of milnacipran, levomilnacipran, may have the capacity to inhibit the activity of beta-site amyloid precursor protein cleaving enzyme-1
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: Ixel 50 mg - Kapseln, IXEL 50 MG KAPSUL, 56 ADETGlimepiride
go.drugbank.com/drugs/DB00222ApprovedInvestigational2 diabetes mellitus. … Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive β cell failure and long-term microvascular and macrovascular
Mixtures: DUERID 30/2 MG TABLET, 30 ADET, DUERID 30/2 MG TABLET, 90 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesIcatibant
go.drugbank.com/drugs/DB06196ApprovedInvestigationalIcatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B<sub>2</sub> receptors with a similar affinity to bradykinin. … It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher than earlier B<sub>2</sub> receptors antagonists, thus representing a new class of medication.
Products: ICATIBANT EG, İKTU 30 MG/3 ML ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADETBavdegalutamide
go.drugbank.com/drugs/DB19032InvestigationalBavdegalutamide is under investigation in clinical trial NCT03888612 (Trial of ARV-110 in Patients With Metastatic Castration Resistant Prostate Cancer).
Synonyms: 3-pyridazinecarboxamide, n-(trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1h-isoindol-5-yl)-1-piperazinyl)methyl)-1-piperidinyl)-, N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1h-isoindol-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamidePhenylephrine
go.drugbank.com/drugs/DB00388ApprovedInvestigationalPhenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil,[L9413] and induce local vasoconstriction.
Synonyms: (−)-m-hydroxy-α-(methylaminomethyl)benzyl alcohol, l-(3-Hydroxyphenyl)-N-methylethanolamineMixtures: DEFLU 300 MG/5 MG/2 MG TABLET, 20 ADET, KONGEST 300 MG/2 MG/5 MG TABLET, 20 ADETOxytocin
go.drugbank.com/drugs/DB00107ApprovedInvestigationalVet approved[A229108,A229113] It is estimated that labor induction with oxytocin is used in almost 10% of deliveries globally. … [A229008,A228593,A229108] Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues.
Mixtures: Bakumokon 5% Minoxidil, Bakumokon 7% Minoxidil SulfateProducts: PITOCIN 10 UNIDADES X ML. AMPOLLETAS, Oxytocin-Richter solution for injection 10 I.U / 1 mlClonidine
go.drugbank.com/drugs/DB00575ApprovedInvestigationalClonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD. … [L7237,L54536,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237]
Synonyms: 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine, 2-((2,6-Dichlorophenyl)imino)imidazolidineMixtures: Combipres 0.1/15 TabFomepizole
go.drugbank.com/drugs/DB01213ApprovedVet approvedFomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesSynonyms: 4-methylpyrazol, 4-methylpyrazole