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Displaying results 3031 - 3040 of 3387 in total

Drug
Technetium Tc-99m ciprofloxacin
go.drugbank.com/drugs/DB05488
Experimental
99mTc-Ciprofloxacin is a new formulation of ciprofloxacin (INFECTON), being investigated as a radioimaging agent for the potential diagnosis of infection, including fever of unknown origin, osteomyelitis, wound infection, abdominal absce...
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
Drug
(R)-warfarin
go.drugbank.com/drugs/DB08496
Experimental
Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in producing an anticoagulant response.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 Substrates
Drug
Tranilast
go.drugbank.com/drugs/DB07615
Investigational
Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. In 1982, it was approved in Japan and South Korea for the management of bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993. It has been...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
Drug
Phloretin
go.drugbank.com/drugs/DB07810
Experimental
Phloretin is a natural dihydrochalcone found in apples and many other fruits.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP3A Inhibitors
Drug
Ademetionine
go.drugbank.com/drugs/DB00118
ApprovedInvestigationalNutraceutical
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Categories: Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
Drug
Menadione
go.drugbank.com/drugs/DB00170
ApprovedNutraceutical
A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP1A2 Inhibitors
Drug
Pyrimethamine
go.drugbank.com/drugs/DB00205
ApprovedInvestigationalVet approved
One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Synonyms: 2,4-Diamino-5-(P-chlorophenyl)-6-ethylpyrimidineCategories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
Drug
Reserpine
go.drugbank.com/drugs/DB00206
ApprovedWithdrawn
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon termin...
Categories: P-glycoprotein inducers, P-glycoprotein inhibitors
Drug
Torasemide
go.drugbank.com/drugs/DB00214
ApprovedInvestigational
Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Substrates
Drug
Glimepiride
go.drugbank.com/drugs/DB00222
ApprovedInvestigational
First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates