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Technetium Tc-99m ciprofloxacin
go.drugbank.com/drugs/DB05488Experimental99mTc-Ciprofloxacin is a new formulation of ciprofloxacin (INFECTON), being investigated as a radioimaging agent for the potential diagnosis of infection, including fever of unknown origin, osteomyelitis, wound infection, abdominal absce...
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme Inhibitors(R)-warfarin
go.drugbank.com/drugs/DB08496ExperimentalWarfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in producing an anticoagulant response.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesTranilast
go.drugbank.com/drugs/DB07615InvestigationalTranilast is an antiallergic drug developed by Kissei Pharmaceuticals. In 1982, it was approved in Japan and South Korea for the management of bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993. It has been...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesPhloretin
go.drugbank.com/drugs/DB07810ExperimentalPhloretin is a natural dihydrochalcone found in apples and many other fruits.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP3A InhibitorsFelbamate
go.drugbank.com/drugs/DB00949ApprovedIt has a weak inhibitory effect on GABA receptor binding sites.
Categories: NMDA Receptor Antagonists, Cytochrome P-450 SubstratesIsoniazid
go.drugbank.com/drugs/DB00951ApprovedInvestigationalAntibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsNorgestimate
go.drugbank.com/drugs/DB00957ApprovedInvestigationalNorgestimate was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with eth...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesPindolol
go.drugbank.com/drugs/DB00960ApprovedInvestigationalPindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythm...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsLetrozole
go.drugbank.com/drugs/DB01006ApprovedInvestigationalLetrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990. It is a third generation aromatase inhibitor like exemestane and anastrozole, meaning it does not significantly affe...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesClobetasol propionate
go.drugbank.com/drugs/DB01013ApprovedInvestigationalClobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It has demonstrated superior activity compared to fluocinonide and was first described in the liter...
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 Substrates