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Displaying results 3041 - 3050 of 3387 in total

Drug
Methoxyflurane
go.drugbank.com/drugs/DB01028
ApprovedInvestigationalVet approvedWithdrawn
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuro...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
Drug
Probenecid
go.drugbank.com/drugs/DB01032
ApprovedInvestigational
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubu...
Synonyms: p-(Dipropylsulfamoyl)benzoic acidCategories: Cytochrome P-450 CYP2C8 Inducers, Cytochrome P-450 CYP3A Inducers
Drug
Tocainide
go.drugbank.com/drugs/DB01056
ApprovedWithdrawn
An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors
Drug
Praziquantel
go.drugbank.com/drugs/DB01058
ApprovedInvestigationalVet approved
Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
Drug
Melatonin
go.drugbank.com/drugs/DB01065
ApprovedInvestigationalNutraceuticalVet approved
Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the ...
Categories: Cytochrome P-450 Substrates, Melatonin Receptor Agonists
Drug
Mequitazine
go.drugbank.com/drugs/DB01071
Investigational
It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors
Drug
Dimethyl sulfoxide
go.drugbank.com/drugs/DB01093
ApprovedInvestigationalVet approved
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue dur...
Categories: Cytochrome P-450 CYP2C19 Inhibitors, Cytochrome P-450 CYP2D6 Inhibitors
Drug
Hesperetin
go.drugbank.com/drugs/DB01094
Investigational
Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
Drug
Pimozide
go.drugbank.com/drugs/DB01100
Approved
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknow...
Categories: Serotonin Receptor Antagonists, Dopamine D2 Receptor Antagonists
Drug
Diazoxide
go.drugbank.com/drugs/DB01119
ApprovedInvestigational
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels. It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors