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Displaying results 3101 - 3110 of 10000 in total
  1. Drug

    Lanthanum carbonate

    go.drugbank.com/drugs/DB06792
    Approved

    It is used to treat elevated phosphate levels, primarily in patients with chronic kidney disease, by binding to dietary phosphate and preventing its absorption in the intestine.[L50733] … Lanthanum carbonate is a phosphate binder marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals.

  2. Drug

    Tislelizumab

    go.drugbank.com/drugs/DB14922
    ApprovedInvestigational

    Tislelizumab is a humanized monoclonal IgG4 antibody against programmed death receptor-1 (PD-1). … It was engineered to have a nullified Fc portion, thus minimizing binding to FcγR on macrophages and limiting treatment resistance via antibody-dependent phagocytosis.

    Categories: Programmed Death Receptor-1 Blocking Antibody
  3. Drug

    Tiopronin

    go.drugbank.com/drugs/DB06823
    Approved

    Tiopronin may also be used to bind metal nanoparticles in Wilson's disease, which is an overload of copper in the body. … It is similar to d-penicillamine in use and efficacy, but offers the advantage of far less adverse effects.

  4. Drug

    Zavegepant

    go.drugbank.com/drugs/DB15688
    ApprovedInvestigational

    Since they inhibit these mechanisms and desensitize neuronal circuits, the use of CGRP receptor antagonists is beneficial in the treatment of migraine. … Zavegepant is a third-generation CGRP receptor antagonist that is small in size and highly soluble. Due to its pharmacological properties, it can be administered intranasally.

    Categories: Calcitonin Gene-Related Peptide Receptor Antagonists
  5. Drug

    Certoparin

    go.drugbank.com/drugs/DB09261
    Approved

    Certoparin is part of the heparins of low molecular weight that presents high activity against the coagulation factor Xa. It is normally used to prevent deep venous thrombosis.

  6. Drug

    Ticagrelor

    go.drugbank.com/drugs/DB08816
    ApprovedInvestigational

    Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. … [A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU,[L14207]. Ticagrelor was granted EMA approval on 3 December 2010.

    Categories: Purinergic P2 Receptor Antagonists, Purinergic P2Y Receptor Antagonists
  7. Drug

    Micafungin

    go.drugbank.com/drugs/DB01141
    ApprovedInvestigational

    It belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.

  8. Drug

    Gemeprost

    go.drugbank.com/drugs/DB08964
    ApprovedWithdrawn

    Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion. … It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone for termination of 1st- and 2nd-trimester pregnancy [A19726].

    Categories: Prostaglandins E, Prostaglandins E, Synthetic
  9. Drug

    Protokylol

    go.drugbank.com/drugs/DB06814
    ApprovedVet approved

    Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States.

    Categories: Agents to Treat Airway Disease, Adrenergic beta-2 Receptor Agonists
  10. Target

    Integrin alpha-V

    go.drugbank.com/bio_entities/BE0003576
    TargetHumans

    ITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). … ITGAV:ITGB3 acts as a receptor for SNED1 and mediates R-G-D-dependent cell adhesion to SNED1 (PubMed:39713860)

    Synonyms: Vitronectin receptor, Vitronectin receptor subunit alpha