Protokylol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Protokylol
DrugBank Accession Number
DB06814
Background

Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States.

Type
Small Molecule
Groups
Approved, Vet approved
Structure
Thumb
Weight
Average: 331.368
Monoisotopic: 331.14197278
Chemical Formula
C18H21NO5
Synonyms
  • Protokylol
  • Protokylolum
  • Protoquilol
External IDs
  • AN 1031
  • JB 251

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
ABeta-2 adrenergic receptor
agonist
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcebutololThe therapeutic efficacy of Acebutolol can be increased when used in combination with Protokylol.
AcetazolamideThe risk or severity of Cardiac Arrhythmia can be increased when Protokylol is combined with Acetazolamide.
AcetyldigitoxinThe risk or severity of Cardiac Arrhythmia can be increased when Protokylol is combined with Acetyldigitoxin.
AclidiniumThe risk or severity of Tachycardia can be increased when Protokylol is combined with Aclidinium.
AcrivastineThe therapeutic efficacy of Protokylol can be increased when used in combination with Acrivastine.
AdenosineThe risk or severity of Tachycardia can be increased when Adenosine is combined with Protokylol.
AlfuzosinThe therapeutic efficacy of Protokylol can be decreased when used in combination with Alfuzosin.
AlimemazineThe therapeutic efficacy of Protokylol can be increased when used in combination with Alimemazine.
AmilorideThe risk or severity of Cardiac Arrhythmia can be increased when Protokylol is combined with Amiloride.
AmitriptylineThe therapeutic efficacy of Protokylol can be decreased when used in combination with Amitriptyline.
Interactions
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Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Protokylol hydrochloride7U7O8Q48IO136-69-6LOVXREQUMZKFCM-UHFFFAOYSA-N
International/Other Brands
Asmetil / Caytine / Palison / Ventaire

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
8Y5Y4EEO2V
CAS number
136-70-9
InChI Key
LUMAEVHDZXIGEP-UHFFFAOYSA-N
InChI
InChI=1S/C18H21NO5/c1-11(6-12-2-5-17-18(7-12)24-10-23-17)19-9-16(22)13-3-4-14(20)15(21)8-13/h2-5,7-8,11,16,19-22H,6,9-10H2,1H3
IUPAC Name
4-(2-{[1-(2H-1,3-benzodioxol-5-yl)propan-2-yl]amino}-1-hydroxyethyl)benzene-1,2-diol
SMILES
CC(CC1=CC=C2OCOC2=C1)NCC(O)C1=CC=C(O)C(O)=C1

References

General References
Not Available
ChemSpider
4798
ChEBI
135413
ChEMBL
CHEMBL1201273
Wikipedia
Protokylol

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.236 mg/mLALOGPS
logP1.29ALOGPS
logP1.48ChemAxon
logS-3.2ALOGPS
pKa (Strongest Acidic)9.86ChemAxon
pKa (Strongest Basic)8.98ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area91.18 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity88.78 m3·mol-1ChemAxon
Polarizability35.44 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Targets

Drugtargets2
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Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Agonist
General Function
Protein homodimerization activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately ...
Gene Name
ADRB2
Uniprot ID
P07550
Uniprot Name
Beta-2 adrenergic receptor
Molecular Weight
46458.32 Da
References
  1. Aggerbeck M, Guellaen G, Hanoune J: N-Aralkyl substitution increases the affinity of adrenergic drugs for the alpha-adrenoceptor in rat liver. Br J Pharmacol. 1979 Jan;65(1):155-9. [Article]

Drug created on September 14, 2010 16:21 / Updated on February 21, 2021 18:52