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Odevixibat
go.drugbank.com/drugs/DB16261ApprovedInvestigationalOdevixibat, or A4250, is an ileal sodium/bile acid cotransporter inhibitor indicated for the treatment of pruritus in patients older than 3 months, with progressive familial intrahepatic cholestasis (PFIC). Odevixibat is the first approv...
Categories: P-glycoprotein substratesOsalmid
go.drugbank.com/drugs/DB16273InvestigationalOsalmid is under investigation in clinical trial NCT03670173 (Safety and Efficacy Assessments of Osalmid in Multiple Myeloma).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesOleic monoethanolamide
go.drugbank.com/drugs/DB16495InvestigationalSynonyms: N-OEA, N-oleoylethanolamineVitis vinifera seed
go.drugbank.com/drugs/DB16606InvestigationalCategories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsVutrisiran
go.drugbank.com/drugs/DB16699ApprovedInvestigational[L34490,L42065] Vutrisiran is commercially available as a conjugate of N-acetylgalactosamine (GalNAc), a residue that enables the delivery of siRNA to hepatocytes.
Hippuric acid
go.drugbank.com/drugs/DB16842ExperimentalSynonyms: N-BenzoylglycineCategories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsL-Acetylleucine
go.drugbank.com/drugs/DB16956ApprovedInvestigational[A264439] Observational studies in patients with Niemann-Pick disease type C (NPC) suggested a beneficial symptomatic as well as neuroprotective disease-modifying effect of the DL-form of N-acetylleucine
Synonyms: N-acetyl leucine, N-acetylleucineCategories: P-glycoprotein inhibitorsSepantronium
go.drugbank.com/drugs/DB17062InvestigationalSepantronium is a compound that suppresses survivin expression in a dose and time-dependent manner, and causes broad-range apoptosis.
Categories: P-glycoprotein substrates