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Displaying results 3111 - 3120 of 10000 in total
  1. Drug

    Cerulenin

    go.drugbank.com/drugs/DB01034
    Experimental

    In fatty acid synthesis, reported to bind in equimolar ratio to b-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. … It is also shown to inhibit feeding and induce dramatic weight loss in mice. It is found naturally in the Cephalosporium caerulensfungus.

  2. Drug

    Orciprenaline

    go.drugbank.com/drugs/DB00816
    Approved

    A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem]

  3. Drug

    Dimazole

    go.drugbank.com/drugs/DB13858
    ApprovedWithdrawn

    Dimazole (diamthazole) is an antifungal. It was withdrawn in Franch in 1972 due to neuropsychiatric reactions.

  4. Drug

    Catridecacog

    go.drugbank.com/drugs/DB09310
    Approved

    Coagulation Factor XIII A-Subunit (Recombinant) is available in the US as the commmercially available product Tretten, and in the EU as NovoThirteen. … Tretten is manufactured as an intracellular, soluble protein in yeast (Saccharomyces cerevisiae) production strain containing the episomal expression vector, pD16.

  5. Drug

    Eluxadoline

    go.drugbank.com/drugs/DB09272
    ApprovedInvestigational

    of abdominal pain and reductions in the Bristol Stool Scale. … The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system and peripherally in the gastrointestinal system.

  6. Drug

    Dapsone

    go.drugbank.com/drugs/DB00250
    ApprovedInvestigational

    It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8) … Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms.

  7. Drug

    Plozalizumab

    go.drugbank.com/drugs/DB12520
    Investigational

    Preclinical studies suggest that CCR2 plays an important role in the trafficking of monocytes and macrophages to sites of inflammation. … The recruitment of macrophages to the arterial wall is believed to be a critical step in the development of atherosclerosis.

  8. Drug

    Droloxifene

    go.drugbank.com/drugs/DB15641
    Experimental

    It may have a particular role in situations in which rapid pharmacokinetics, or an increased antiestrogenic to estrogenic ratio, are required. … Droloxifene may have an effect on bone and breast tissue because it induces apoptosis.

    Categories: Compounds used in a research, industrial, or household setting
  9. Drug

    Tarenflurbil

    go.drugbank.com/drugs/DB05289
    Investigational

    Tarenflurbil is an investigational drug that was studied in patients with mild Alzheimer's disease. … It is a selective amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (Aβ42) in cultured human cells and in animal models.

  10. Drug

    Dihydroergocornine

    go.drugbank.com/drugs/DB11273
    Approved

    [A32962] It is an artificial derivative of the crude extract of ergot and later purified, ergocornine. … [A32964] The formation of dihydroergocornine implies the hydrogenation of the double bonds in the lysergic acid.