Search
Pexidartinib
go.drugbank.com/drugs/DB12978ApprovedInvestigational[A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients. … [L7901] While surgical resection is a current standard of care for tenosynovial giant cell tumor, there are tumor types where surgeries are deemed clinically ineffective with a high risk of lifetime
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexTrofinetide
go.drugbank.com/drugs/DB06045Approved[A258453] Trofinetide is marketed as DAYBUE and DAYBUE STIX in the United States, as DAYBUE in Canada, and as DAYBU in the European Union. … Trofinetide is a novel synthetic analog of [glypromate], also known as glycine–proline–glutamate (GPE), a naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor
Ecopladib
go.drugbank.com/drugs/DB19921ExperimentalEcopladib is a small molecule drug. The usage of the INN stem '-pladib' in the name indicates that Ecopladib is a phospholipase A2 inhibitor. … Ecopladib has a monoisotopic molecular weight of 746.12 Da.
Categories: Phospholipase A2 InhibitorsElesclomol
go.drugbank.com/drugs/DB05719Investigationaladditional toxicity, at moderate doses. … In preclinical models elesclomol showed potent killing of a broad range of cancer cell types at high doses, and an ability to strongly enhance the efficacy of certain chemotherapy agents, with minimal
8-chlorotheophylline
go.drugbank.com/drugs/DB14132ExperimentalIts main use is in combination with [Diphenhydramine] as the antiemetic drug [Dimenhydrinate]. … 8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine.
Phthalylsulfathiazole
go.drugbank.com/drugs/DB13248ApprovedPhthalylsulfathiazole is a broad spectrum antibiotic which is part of the drug class, sulfonamides. It was used as an antibiotic for bowel surgery, and for infections of the colon [A175006].
Ceftobiprole medocaril
go.drugbank.com/drugs/DB14733ApprovedCeftobiprole medocaril is a prodrug of [ceftobiprole], a fifth-generation semisynthetic cephalosporin antibacterial. … Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains of _Staphylcoccus aureus_ (methicillin-resistant
Amylmetacresol
go.drugbank.com/drugs/DB13908ApprovedAmylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections [L2570], [L2571]. … Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils [L2575].
Synonyms: 6-amyl-m-cresol, 6-n-amyl-m-cresolFidanacogene elaparvovec
go.drugbank.com/drugs/DB16783ApprovedInvestigationalFidanacogene elaparvovec is a liver-specific adeno-associated virus (AAV) vector containing a codon-optimized human coagulation FIX gene that was investigated as a potential treatment for hemophilia B. … Current available treatments include substitution therapy involving the intravenous administration of standard factor IX once a week for bleeding or as prophylaxis and 2–3 times a week for severe hemophilia
Synthetic Conjugated Estrogens, A
go.drugbank.com/drugs/DB09317ApprovedThere is currently no generic form of CEEs available as a detailed analytical characterization of the active ingredients or of their estrogenic activity is not available at this time. … However, once a woman stops ovulating there is a sharp decline in the production of progesterone and estradiol by the ovaries and a consequent fluctuation in LH and FSH due to a lack of feedback control
Synonyms: Estrogens, Conjugated Synthetic A, Synthetic Conjugated Estrogens, A